CAREER: Selective Patterning and Transport of Functionalized Inorganic Nanoparticles

该职业奖授予宾夕法尼亚州立大学的Mary Beth Williams教授，由分析和表面化学项目支持，重点研究通过控制纳米颗粒的运输和沉积来选择表面图案。在最小的尺度上，功能化磁性纳米粒子和半导体纳米晶体将被制备并使用配体交换策略附着在表面上。这些粒子将具有可合成调节的磁性和发光特性。磁性纳米颗粒将用于制造超高密度的磁阵列，并能够通过磁力显微镜成像来探测单个纳米颗粒的磁性。在溶液中自由扩散的、具有化学功能的磁性纳米颗粒的传输将由外加磁场梯度控制，从而使纳米颗粒的定向传输成为可能，以输送回收的目标分析物。此外，纳米颗粒将选择性地附着在生物分子运动蛋白上，在ATP水解和与磁场梯度对齐后，将进一步实现选择性和快速的颗粒运动。长期应用包括药物输送、环境修复和电子设备。颗粒磁性和颗粒表面化学的独立控制扩大了应用范围。拓展活动包括在本科和高中阶段提供指导。实验室研究活动范围广泛，包括一系列实验室技术，包括口头和书面报告以及出席会议。对于年轻科学家来说，可获得的科学文献中存在空白；到目前为止，《化学教育杂志》上只有一篇关于纳米粒子的文章。因此，一个关于纳米粒子合成和表征的子项目将被承担，导致一篇适合年轻理科生的文献。

This CAREER award to Professor Mary Beth Williams of the Pennsylvania State University, supported by the Analytical and Surface Chemistry Program, focuses on the selective patterning of surfaces with nanoparticles by controlled transport and deposition. At the smallest scales, functionalized magnetic nanoparticles and semiconductor nanocrystals will be prepared and attached to surfaces using ligand exchange strategies. The particles will have synthetically adjustable magnetic and luminescent properties. The magnetic nanoparticles will be used to produce ultrahigh density magnetic arrays and enable the interrogation of the magnetic properties of individual nanoparticles via magnetic force microscopy imaging. The transport of freely diffusing, chemically functional magnetic nanoparticles in solution will be controlled by applied magnetic field gradients, making possible the directed transport of nanoparticles for the delivery of recovery of target analytes. Also, nanoparticles will be selectively attached to biomolecular motor proteins that, upon hydrolysis of ATP and alignment with magnetic field gradients, will further enable selective and rapid particle motion. The long-term applications include drug delivery, environmental remediation, and electronic devices. The range of applications is broadened with the independent control of particle magnetism and particle surface chemistry. Outreach activities include mentoring at the undergraduate and high school level. The laboratory research activities are wide-ranging, encompassing a range of laboratory techniques and including oral and written presentations and attendance at meetings. For the young scientist, a gap in the accessible scientific literature is noted; as yet, there is only a single publication on nanoparticles in the Journal of Chemical Education. Thus, a subproject on nanoparticle synthesis and characterization will be undertaken, leading to a literature appropriate for the young science student.