CAREER: Selective Patterning and Transport of Functionalized Inorganic Nanoparticles

这个职业奖授予宾夕法尼亚州立大学的玛丽贝丝威廉姆斯教授，由分析和表面化学计划支持，重点是通过控制传输和沉积用纳米颗粒选择性图案化表面。 在最小的尺度上，功能化的磁性纳米颗粒和半导体纳米晶体将被制备并使用配体交换策略附着到表面。 这些颗粒将具有可综合调节的磁性和发光特性。 磁性纳米颗粒将用于产生高密度磁性阵列，并通过磁力显微镜成像对单个纳米颗粒的磁性进行询问。 自由扩散的化学功能磁性纳米颗粒在溶液中的运输将通过施加的磁场梯度来控制，使得定向运输纳米颗粒用于递送目标分析物的回收成为可能。 此外，纳米颗粒将选择性地附着于生物分子马达蛋白，在ATP水解并与磁场梯度对齐时，生物分子马达蛋白将进一步实现选择性和快速的颗粒运动。 长期应用包括药物输送、环境修复和电子设备。 通过对粒子磁性和粒子表面化学的独立控制，拓宽了应用范围。 外联活动包括在本科和高中一级提供辅导。 实验室的研究活动是广泛的，包括一系列的实验室技术，包括口头和书面介绍和出席会议。 对于这位年轻的科学家来说，在可访问的科学文献中存在着一个空白;到目前为止，在《化学教育杂志》上只有一个关于纳米粒子的出版物。 因此，纳米粒子的合成和表征的子项目将进行，导致适合年轻的科学学生的文献。

This CAREER award to Professor Mary Beth Williams of the Pennsylvania State University, supported by the Analytical and Surface Chemistry Program, focuses on the selective patterning of surfaces with nanoparticles by controlled transport and deposition. At the smallest scales, functionalized magnetic nanoparticles and semiconductor nanocrystals will be prepared and attached to surfaces using ligand exchange strategies. The particles will have synthetically adjustable magnetic and luminescent properties. The magnetic nanoparticles will be used to produce ultrahigh density magnetic arrays and enable the interrogation of the magnetic properties of individual nanoparticles via magnetic force microscopy imaging. The transport of freely diffusing, chemically functional magnetic nanoparticles in solution will be controlled by applied magnetic field gradients, making possible the directed transport of nanoparticles for the delivery of recovery of target analytes. Also, nanoparticles will be selectively attached to biomolecular motor proteins that, upon hydrolysis of ATP and alignment with magnetic field gradients, will further enable selective and rapid particle motion. The long-term applications include drug delivery, environmental remediation, and electronic devices. The range of applications is broadened with the independent control of particle magnetism and particle surface chemistry. Outreach activities include mentoring at the undergraduate and high school level. The laboratory research activities are wide-ranging, encompassing a range of laboratory techniques and including oral and written presentations and attendance at meetings. For the young scientist, a gap in the accessible scientific literature is noted; as yet, there is only a single publication on nanoparticles in the Journal of Chemical Education. Thus, a subproject on nanoparticle synthesis and characterization will be undertaken, leading to a literature appropriate for the young science student.