Folding Dendrimers: Driving Macromolecular Self-Organization With Intramolecular Hydrogen-Bonding and Packing Interactions

折叠树枝状聚合物：通过分子内氢键和堆积相互作用驱动大分子自组织

• 批准号: 0239871
• 负责人: Jon Parquette
• 金额: $ 37.2万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239871&HistoricalAwards=false
• 关键词: Folding; Dendrimers; Driving; Macromolecular; Self

The focus of this research involves dendrimeric molecules. Understanding the effect of global/local cooperativity in dendrimer folding, evaluation of the effect of aqueous media on the folding properties of dendrimers, correlation of peptide helicity and dendrimer folding, transferring chirality from the central core to the periphery of a dendrimer,and, interconverting global conformations with light will be the specific goals of the project.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Jonathan R. Parquette of the Department of Chemistry at the Ohio State University. Dr. Parquette will focus his work on the control of the folding process of a synthetic dendrimer by understanding how various elements of structural order cooperate to create a compact, three- dimensional structure. The project has potential broad impact for nanotechnology and provides an excellent venue for the interdisciplinary training of students at the undergraduate and graduate level.

这项研究的重点涉及树枝状分子。 了解树枝状聚合物折叠中的全局/局部协同效应，评估水介质对树枝状聚合物折叠特性的影响，肽螺旋度和树枝状聚合物折叠的相关性，将手性从树枝状聚合物的中心核心转移到外围，以及将全局构象与光相互转换将是该项目的具体目标。有机和大分子化学计划正在支持乔纳森·R·俄亥俄州州立大学化学系的Parquette博士说。 Parquette博士将通过了解结构顺序的各种元素如何合作创造一个紧凑的三维结构，将他的工作重点放在控制合成树枝状聚合物的折叠过程上。 该项目对纳米技术具有潜在的广泛影响，并为本科生和研究生的跨学科培训提供了一个很好的场所。