Self-Assembly of Multicomponent Nanostructures

多组分纳米结构的自组装

• 批准号: 2106924
• 负责人: Jon Parquette
• 金额: $ 52.5万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2106924&HistoricalAwards=false
• 关键词: Self; Assembly; Multicomponent; Nanostructures

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the NSF Division of Chemistry, Professor Jon Parquette of Ohio State University will develop new strategies to construct multicomponent nanomaterials via the self-assembly of simple building blocks. The capability to build abiological nanomaterials comprised of discrete, self-sorted domains is expected to enable the emergence of novel properties that will drive the development of novel biomaterials, drug delivery modalities, catalysts, and optoelectronic materials. This work will create a platform to also address other problems in human health and society, such as renewable energy, greenhouse gas conversion, and medicine. This project will be used to enhance public awareness of nanoscience in society and will expose a diversity of students to scientific research. The PI will achieve these goals by supervising undergraduate and high school students in research, by mentoring undergraduate career clubs, and by participating in science exhibitions at Columbus Center of Science and Industry (COSI) as a member the Center of Applied Plant Science (CAPS) at Ohio State University.This research aims to gain a better fundamental understanding of the factors that govern "self/non-self" interaction at the nanostructure level and to establish new design principles to construct multicomponent hierarchical architectures by the coassembly of spatially sorted domains of components. This is important because the nanoscale organization of the components of an assembled structure critically impacts the functional attributes of a nanomaterial. The first aim of this work will construct block sequences of two types of supramolecular rings within a self-assembled nanotube via a heterogeneous nucleation-elongation mechanism. The second aim facilitates the interactions between the separate domains by incorporating an intervening polydopamine layer to stabilize one component and mediate further interactions with additional assembled structures. Transient nanostructures that only persist in the presence of fuel play critical roles in living cells, such as controlling the mechanical properties of the cytoskeleton. Thus, the third aim of this work will focus on the design of transient multicomponent hydrogels that exhibit time-dependent physical/optical characteristics, whose temporal evolution can be directly visualized using confocal light microscopy.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在美国国家科学基金会化学部高分子、超分子和纳米化学项目的支持下，俄亥俄州立大学的乔恩·帕奎特教授将开发新策略，通过简单构件的自组装来构建多组分纳米材料。构建由离散的自排序域组成的非生物纳米材料的能力预计将能够出现新的特性，从而推动新型生物材料、药物输送方式、催化剂和光电材料的发展。这项工作还将创建一个平台来解决人类健康和社会的其他问题，例如可再生能源、温室气体转化和医学。该项目将用于提高社会公众对纳米科学的认识，并使多样化的学生接触科学研究。 PI 将通过指导本科生和高中生的研究、指导本科生职业俱乐部以及作为俄亥俄州立大学应用植物科学中心 (CAPS) 的成员参加哥伦布科学与工业中心 (COSI) 的科学展览来实现这些目标。这项研究旨在更好地了解纳米结构水平上控制“自/非自”相互作用的因素，并建立新的设计原则来构建 通过空间排序的组件域的组合来构建多组件层次结构。 这很重要，因为组装结构组件的纳米级组织严重影响纳米材料的功能属性。这项工作的第一个目标是通过异质成核-伸长机制在自组装纳米管内构建两种类型超分子环的嵌段序列。第二个目标是通过掺入中间聚多巴胺层来稳定一个组分并介导与其他组装结构的进一步相互作用，从而促进单独域之间的相互作用。仅在燃料存在下持续存在的瞬态纳米结构在活细胞中发挥着关键作用，例如控制细胞骨架的机械性能。因此，这项工作的第三个目标将集中于设计具有时间依赖性物理/光学特性的瞬态多组分水凝胶，其时间演变可以使用共焦光学显微镜直接可视化。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Co-assembly of a multicomponent network of nanofiber-wrapped nanotubes

纳米纤维包裹的纳米管多组分网络的共组装

• DOI: 10.1039/d1nr08508e
• 发表时间: 2022
• 期刊: Nanoscale
• 影响因子: 6.7
• 作者: Mason, McKensie L.;Lin, Tao;Linville, Jenae J.;Parquette, Jon R.
• 通讯作者: Parquette, Jon R.

Light-driven dissipative self-assembly of a peptide hydrogel

• DOI: 10.1039/d1cc04971b
• 发表时间: 2021-11-29
• 期刊: CHEMICAL COMMUNICATIONS
• 影响因子: 4.9
• 作者: Liu, Mengmeng;Creemer, Cassidy N.;Parquette, Jon R.
• 通讯作者: Parquette, Jon R.

Dissipative self-assembly of a proline catalyst for temporal regulation of the aldol reaction

脯氨酸催化剂的耗散自组装用于羟醛反应的时间调节

• DOI: 10.1039/d2nr03991e
• 发表时间: 2022
• 期刊: Nanoscale
• 影响因子: 6.7
• 作者: Reardon, Thomas J.;Na, Baichuan;Parquette, Jon R.
• 通讯作者: Parquette, Jon R.

Self-assembly of a 5-fluorouracil and camptothecin dual drug dipeptide conjugate

5-氟尿嘧啶和喜树碱双药二肽缀合物的自组装

• DOI: 10.1039/d2ob00762b
• 发表时间: 2022
• 期刊: Organic & Biomolecular Chemistry
• 影响因子: 3.2
• 作者: Sun, Yuan;Fry, Cathleen M.;Shieh, Aileen;Cai, Xiangchen;Reardon, Thomas J.;Parquette, Jon R.
• 通讯作者: Parquette, Jon R.