CAREER: Development of Conformational Order in Chiral, Amphiphilic, Dendrimers and Application to Enantioselective Catalysis in Aqueous Media

职业：手性、两亲性、树枝状聚合物构象顺序的发展及其在水介质中对映选择性催化的应用

• 批准号: 9875458
• 负责人: Jon Parquette
• 金额: $ 35.34万
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9875458&HistoricalAwards=false
• 关键词: CAREER; Development; Conformational; Order; Chiral

Professor Parquette plans to study the chemistry of dendrimers and hyperbranched polymers with a view toward their use as chiral reagents and phase-transfer catalysts. Chirality will be explored by incorporating an asymmetric core that is nonracemic and studying its effects on the conformation of dendridic arms that evolve from that core. Ultimate applications of such structures center on the provision of chiral pockets wherein bimolecular reaction rates will be increased due to hydrophobic compression. Phase-transfer catalysis stems from the design of dendrimers having hydrophobic cores and hydrophilic surface structures, wherein polar reaction product derived from nonpolar reactants will be expelled into the reaction medium. Professor Parquette will also initiate a program of cooperative learning groups among undergraduate organic chemistry students. Students' progress will be monitored through the use of log books and audits of tests earning "C" or below will be instituted. Attention will be paid to providing research opportunities to undergraduates at this large public university. Additionally, a Chemistry Resource Center will provide a means for students to access mentorship and assistance while economizing the time of participating faculty.With this CAREER award, the Synthetic Organic Program supports the teaching and research program of Dr. Jonathan R. Parquette of Ohio State University. Professor Parquette's research is in the area of dendrimers, a specialized polymer molecule that emanates in a spherical manner from a central core structure. The goal is to control the three-dimensional aspect of these dendrimers so that they will be able to transmit that three-dimensional control through a chemical reaction and into the product structure. Such molecules that can act as catalysts in this manner are especially sought after. Professor Parquette is also embarking upon several strategies to decrease the effective student-teacher ratio in chemistry classes at Ohio State by developing cooperative learning strategies and by starting a Chemistry Resource Center to more effectively utilize faculty time. Web-based dissemination of course material will also be employed to more effectively communicate with students.

帕奎特教授计划研究树枝状大分子和超支化聚合物的化学，以期将它们用作手性试剂和相转移催化剂。手性将通过结合非外消旋的不对称核心并研究其对从该核心进化出的树枝状臂的构象的影响来探索。这种结构的最终应用集中在提供手性口袋，其中双分子反应速率将由于疏水压缩而增加。相转移催化源于具有疏水核心和亲水表面结构的树状大分子的设计，其中非极性反应物产生的极性反应产物将被排放到反应介质中。帕奎特教授还将在本科生有机化学学生中发起一个合作学习小组计划。学生的进步将通过使用日志来监测，并将对得分为C或以下的考试进行审计。将注重为这所大型公立大学的本科生提供研究机会。此外，化学资源中心将为学生提供指导和帮助的手段，同时节省参与教师的时间。有了这个职业奖，合成有机计划支持俄亥俄州立大学乔纳森·R·帕奎特博士的教学和研究计划。帕奎特教授的研究领域是树枝状大分子，这是一种特殊的聚合物分子，从中心核心结构以球形方式发出。我们的目标是控制这些树状大分子的三维结构，以便它们能够通过化学反应将三维控制传递到产品结构中。这类能够以这种方式充当催化剂的分子尤其受到追捧。帕奎特教授还在着手制定几项策略，通过开发合作学习策略和成立化学资源中心来更有效地利用教师时间，以降低俄亥俄州立大学化学课堂上的有效师生比例。课程材料的网上传播也将被用于更有效地与学生沟通。