CAREER: Development of Conformational Order in Chiral, Amphiphilic, Dendrimers and Application to Enantioselective Catalysis in Aqueous Media

Parquette教授计划研究树枝状聚合物和超支化聚合物的化学，以期将其用作手性试剂和相转移催化剂。 手性将探讨通过纳入一个不对称的核心，是nonracematic和研究其对构象的树枝状武器，从该核心演变的影响。 这种结构的最终应用集中在提供手性口袋上，其中双分子反应速率将由于疏水压缩而增加。 相转移催化源于具有疏水核和亲水表面结构的树枝状聚合物的设计，其中衍生自非极性反应物的极性反应产物将被排出到反应介质中。 Parquette教授还将在本科有机化学学生中发起合作学习小组计划。 学生的进步将通过使用日志进行监测，并对考试成绩“C”或以下的考试进行审计。 将注意为这所大型公立大学的本科生提供研究机会。 此外，化学资源中心将为学生提供一种获得指导和帮助的手段，同时节省参与教师的时间。有了这个职业奖，合成有机计划支持博士的教学和研究计划。俄亥俄州州立大学的帕奎特。 Parquette教授的研究领域是树枝状聚合物，这是一种特殊的聚合物分子，从中心核心结构以球形方式散发出来。 目标是控制这些树枝状聚合物的三维方面，以便它们能够通过化学反应将三维控制传递到产品结构中。 特别需要能够以这种方式起催化剂作用的分子。 Parquette教授还着手制定了几项策略，通过制定合作学习策略和启动化学资源中心来更有效地利用教师的时间，以减少俄亥俄州化学课的有效师生比例。 还将利用网络传播课程材料，以便更有效地与学生沟通。

Professor Parquette plans to study the chemistry of dendrimers and hyperbranched polymers with a view toward their use as chiral reagents and phase-transfer catalysts. Chirality will be explored by incorporating an asymmetric core that is nonracemic and studying its effects on the conformation of dendridic arms that evolve from that core. Ultimate applications of such structures center on the provision of chiral pockets wherein bimolecular reaction rates will be increased due to hydrophobic compression. Phase-transfer catalysis stems from the design of dendrimers having hydrophobic cores and hydrophilic surface structures, wherein polar reaction product derived from nonpolar reactants will be expelled into the reaction medium. Professor Parquette will also initiate a program of cooperative learning groups among undergraduate organic chemistry students. Students' progress will be monitored through the use of log books and audits of tests earning "C" or below will be instituted. Attention will be paid to providing research opportunities to undergraduates at this large public university. Additionally, a Chemistry Resource Center will provide a means for students to access mentorship and assistance while economizing the time of participating faculty.With this CAREER award, the Synthetic Organic Program supports the teaching and research program of Dr. Jonathan R. Parquette of Ohio State University. Professor Parquette's research is in the area of dendrimers, a specialized polymer molecule that emanates in a spherical manner from a central core structure. The goal is to control the three-dimensional aspect of these dendrimers so that they will be able to transmit that three-dimensional control through a chemical reaction and into the product structure. Such molecules that can act as catalysts in this manner are especially sought after. Professor Parquette is also embarking upon several strategies to decrease the effective student-teacher ratio in chemistry classes at Ohio State by developing cooperative learning strategies and by starting a Chemistry Resource Center to more effectively utilize faculty time. Web-based dissemination of course material will also be employed to more effectively communicate with students.