CAREER: Development of Conformational Order in Chiral, Amphiphilic, Dendrimers and Application to Enantioselective Catalysis in Aqueous Media

Parquette教授计划研究树状大分子和超支化聚合物的化学性质，以期将它们用作手性试剂和相转移催化剂。手性将通过纳入非外消旋的不对称核并研究其对从该核进化而来的枝状臂构象的影响来探索。这种结构的最终应用集中在提供手性口袋上，其中由于疏水压缩，双分子反应速率将增加。相转移催化源于具有疏水核和亲水表面结构的树状大分子的设计，其中由非极性反应物产生的极性反应产物将被排出到反应介质中。帕奎特教授还将在有机化学本科学生中发起一项合作学习小组计划。将通过使用日志簿来监测学生的进步，并对成绩为“C”或以下的考试进行审计。这所大型公立大学将注重为本科生提供研究机会。此外，化学资源中心将为学生提供获得指导和帮助的手段，同时节省参与教师的时间。有了这个职业奖，合成有机项目支持俄亥俄州立大学乔纳森·r·帕奎特博士的教学和研究项目。Parquette教授的研究方向是树状大分子，这是一种特殊的聚合物分子，从中心核心结构以球形的方式发散出来。我们的目标是控制这些树状大分子的三维结构，这样它们就能通过化学反应将三维控制传递到产物结构中。这种能以这种方式充当催化剂的分子尤其受到人们的追捧。帕奎特教授还着手实施了几项策略，通过开发合作学习策略和启动化学资源中心来更有效地利用教师时间，从而降低俄亥俄州立大学化学课的有效师生比例。课程资料的网络传播也将被用来更有效地与学生沟通。

Professor Parquette plans to study the chemistry of dendrimers and hyperbranched polymers with a view toward their use as chiral reagents and phase-transfer catalysts. Chirality will be explored by incorporating an asymmetric core that is nonracemic and studying its effects on the conformation of dendridic arms that evolve from that core. Ultimate applications of such structures center on the provision of chiral pockets wherein bimolecular reaction rates will be increased due to hydrophobic compression. Phase-transfer catalysis stems from the design of dendrimers having hydrophobic cores and hydrophilic surface structures, wherein polar reaction product derived from nonpolar reactants will be expelled into the reaction medium. Professor Parquette will also initiate a program of cooperative learning groups among undergraduate organic chemistry students. Students' progress will be monitored through the use of log books and audits of tests earning "C" or below will be instituted. Attention will be paid to providing research opportunities to undergraduates at this large public university. Additionally, a Chemistry Resource Center will provide a means for students to access mentorship and assistance while economizing the time of participating faculty.With this CAREER award, the Synthetic Organic Program supports the teaching and research program of Dr. Jonathan R. Parquette of Ohio State University. Professor Parquette's research is in the area of dendrimers, a specialized polymer molecule that emanates in a spherical manner from a central core structure. The goal is to control the three-dimensional aspect of these dendrimers so that they will be able to transmit that three-dimensional control through a chemical reaction and into the product structure. Such molecules that can act as catalysts in this manner are especially sought after. Professor Parquette is also embarking upon several strategies to decrease the effective student-teacher ratio in chemistry classes at Ohio State by developing cooperative learning strategies and by starting a Chemistry Resource Center to more effectively utilize faculty time. Web-based dissemination of course material will also be employed to more effectively communicate with students.