Reactivity and Synthesis of Fluoroorganic Compounds and Reactive Intermediates

含氟有机化合物及反应中间体的反应性及合成

• 批准号: 0239884
• 负责人: William Dolbier
• 金额: --
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239884&HistoricalAwards=false
• 关键词: Reactivity; Synthesis; Fluoroorganic; Compounds; Reactive

The focus of this research is to study the reactivity of sulfurpentafluoride radicals and trifluoromethane anions (Ruppert's reagent) for the preparation of fluoronated organic compounds. This study involves the elaboration of detailed reaction mechanisms by the use of thermodynamics and kinetics to examine regiochemical and stereochemical issues as they apply to structure-activity relationships in the reaction intermediates. With this continuing award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. William R. Dolbier, Jr. of the Department of Chemistry at the University of Florida. Professor Dolbier will focus his work on the construction of commercially feasible methods for the preparation of materials for use in the semiconductor industry. Methods for safe, economical and environmentally friendly methods for the production of organofluorine compounds will be developed. The educational activities of the award will include the training of graduate students, post-doctoral associates, visiting scholars and undergraduates at the University of Florida.

本研究的重点是研究硫五氟化自由基与三氟甲烷阴离子（鲁珀特试剂）在氟化有机化合物制备中的反应性。本研究涉及通过使用热力学和动力学来详细阐述反应机制，以检查区域化学和立体化学问题，因为它们适用于反应中间体的结构-活性关系。有了这个持续的奖项，有机和大分子化学项目支持了佛罗里达大学化学系的William R. Dolbier博士的研究和教育工作。Dolbier教授将专注于构建商业上可行的方法，以制备用于半导体工业的材料。将开发安全、经济和环境友好的生产有机氟化合物的方法。该奖项的教育活动将包括培训佛罗里达大学的研究生、博士后助理、访问学者和本科生。