FGF10 signaling in distal/alveolar epithelial progenitor cells - role in lung fibrosis

远端/肺泡上皮祖细胞中的 FGF10 信号传导 - 在肺纤维化中的作用

• 批准号: 161184405
• 负责人: Professor Dr. Saverio Bellusci
• 金额: --
• 依托单位: Medizinische Klinik und Poliklinik II: Pneumologie, Gastroenterologie, Nephrologie und Internistische Intensivmedizin
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/161184405?language=en
• 关键词: FGF10; signaling; distal; alveolar; epithelial

This grant application is based on our preliminary data recently accepted for publication since the previous submission (Gupte et al., 2009) indicating that Fibroblast growth factor 10 (Fgf10) overexpression in the lung during the inflammatory or fibrotic phase leads to fibrosis attenuation in a mouse model of bleomycin-induced fibrosis. The Central hypothesis that will be tested is: FGF10 controls the proliferation and differentiation of the pulmonary epithelial progenitor cells during the repair process, thereby affecting lung fibroproliferative processes. Three Aims are proposed: Aim 1: To determine the role of FGF10 during repair after injury in a model of inflammation-driven pulmonary fibrosis Aim 2: To determine the capability of FGF10 to reverse fibroproliferative events in a non- inflammatory lung fibrosis model Aim 3: To determine whether endogenous FGFR2b signaling is required for the repair process leading to attenuation of fibrosis in mice.

该资助申请是基于我们自上次提交以来最近接受出版的初步数据（Gupte等人，2009），表明在炎症或纤维化阶段期间肺中的成纤维细胞生长因子10（Fgf 10）过表达导致博来霉素诱导的纤维化的小鼠模型中的纤维化衰减。将要检验的中心假设是：FGF10在修复过程中控制肺上皮祖细胞的增殖和分化，从而影响肺纤维增生过程。提出了三个目标：目标1：目的2：确定FGF 10逆转非炎性肺纤维化模型中纤维增生事件的能力目的3：确定内源性FGFR 2b信号传导是否是导致小鼠纤维化减弱的修复过程所需的。

项目成果

miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development

• DOI: 10.1242/dev.105908
• 发表时间: 2014-03-15
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: Carraro, Gianni;Shrestha, Amit;Bellusci, Saverio
• 通讯作者: Bellusci, Saverio

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally

• DOI: 10.1242/dev.099747
• 发表时间: 2014-01-15
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: El Agha, Elie;Herold, Susanne;Bellusci, Saverio
• 通讯作者: Bellusci, Saverio