Solid Models for Teaching and Research

虽然分子模型在研究和教学中发挥了至关重要的作用超过100年，今天，这些模型主要是由计算机图形显示，在某些方面是强大的，但在其他方面缺乏。 为了平衡这种情况，已经编写了一个计算机程序（SCULPT），通过使用蛋白质数据库中的原子坐标来创建大分子选定区域的实体模型。 这些模型是用蜡、木头或其他材料制成的，其比例与商业上可获得的原子模型相对应。 这利用能够加工木材（10，000rmp主轴速度）的专用计算机数控（CNC）铣床，并且其足够大以构建最典型的大分子结合或受体位点的模型。 一名教育顾问协助编写学习指南和课堂材料，用于教授高中生物和化学高级课程的学生。 私家侦探积极参与本科生和研究生的生物化学教学。 研究应用程序来自他的实验室和与其他团体的合作。

Although molecular models have played a crucial role in research and teaching for over 100 years, today these models primarily are generated by computer graphics displays that are powerful in some respects but lacking in others. In order to bring balance to this situation, a computer program (SCULPT) has been written to create solid models of selected regions of macromolecules by using atomic coordinates from the Protein Data Bank. These model are constructed in wax, wood, or other materials to a scale corresponding to commercially available atomic models. This utilizes a dedicated computer numeric controlled (CNC) milling machine capable of machining wood (10,000rmp spindle speed) and large enough to build a model of most typical macromolecular binding or receptor sites. An educational consultant assists with the preparation of study guides and classroom materials for teaching high school advanced placement biology and chemistry students. The P.I. is actively involved in undergraduate and graduate teaching of biochemistry students. Research applications are derived from his laboratory and from collaborations with other groups.