Genomics & Computational Biology: an REU Site

在基因组学和计算生物学的动手研究将带来10名参与者招募全国代表性不足的群体到UGA，在那里他们将与一个既定的跨学科团队进行互动，致力于确定基本过程的生物电路，并通过将其拟合到基因组学数据来验证这些生物电路。 自从60年前发现DNA作为遗传物质以来，生物学家一直在以越来越精细的尺度分解生命系统，直到我们能够确定许多生物体的完整遗传蓝图。 新千年的挑战是“重新组合碎片”，即，从基因组到生命 重组这些碎片的一种方法是借用计算机科学的一个比喻：描述细胞行为的整个化学反应网络是一个生物电路。 这个基因组学和计算生物学项目的主题是“计算生命”，即，识别用于基本过程如碳代谢的生物回路并通过将这些生物回路与描述细胞正在做什么的基因组学数据拟合来验证这些生物回路（即，RNA和蛋白质谱数据）（PNAS 99：16904-16909（2002））。 欲了解更多信息，请联系lindalee@uga.edu或访问http://gene.genetics.uga.edu/stc。 该网站由国防部与NSF REU计划合作提供支持

Hands-on research in Genomics and Computational Biology will bring 10 participants recruited nationally from underrepresented groups to UGA, where they will interact with an established interdisciplinary team working on identifying biological circuits for fundamental processes and validating these biological circuits by fitting them to genomics data. Since the discovery of DNA as the genetic material 60 years ago, biologists have been taking apart living systems on a finer and finer scale until we have been able to determine the complete genetic blueprint of many organisms. The challenge of the new millennium is "reassembling the pieces", i.e., moving from genomes to life. One approach to reassembling the pieces is to borrow a metaphor from computer science: the entire chemical reaction network describing what a cell does is a biological circuit. The theme for this genomics and computational biology program is "computing life", i.e., identifying biological circuits for fundamental processes like carbon metabolism and validating these biological circuits by fitting them to genomics data describing what the cell is doing (i.e., RNA and protein profiling data) (PNAS 99: 16904-16909 (2002)). For more information contact lindalee@uga.edu or visit http://gene.genetics.uga.edu/stc. This site is supported by the Department of Defense in partnership with the NSF REU program