National Science Foundation: Alan T. Waterman Award

美国国家科学基金会：艾伦·T·沃特曼奖

• 批准号: 0244319
• 负责人: Jennifer Doudna
• 金额: $ 46.49万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0244319&HistoricalAwards=false
• 关键词: National; Science; Foundation; Alan; T.

ALAN T. WATERMAN AWARD Jennifer A. Doudna(0003240)ABSTRACTJennifer A. Doudna, a Professor at Yale University in the Department of Molecular Biophysics and Biochemistry is the recipient of the 2000 Alan T. Waterman award. She has conducted innovative research that led to the development of a technique that facilitates crystallization of large RNA molecules, has determined the crystal structure of catalytic RNA molecules and a RNA molecule that forms the ribonucleoprotein core of the signal recognition particle, and has deciphered structural features of those molecules that permit a greater understanding of the mechanistic basis of RNA function in both catalysis and in protein synthesis. Her current research is reshaping basic theories regarding the roles of metal ions in ribozyme function. No longer viewed as strict metalloenzymes, some ribozymes can access alternative catalytic mechanisms depending on the identity and availability of metal ions. Similarly, reaction conditions can allow different folding pathways to predominate, with divalent cations sometimes playing opposing roles.

艾伦·T水人奖詹妮弗·A. Doudna（0003240）摘要Jennifer A.杜德纳是耶鲁大学分子生物物理学和生物化学系的教授，他是2000年艾伦·T。沃特曼奖 她进行了创新研究，导致开发了一种促进大RNA分子结晶的技术，确定了催化RNA分子和形成信号识别颗粒核糖核蛋白核心的RNA分子的晶体结构，并破译了这些分子的结构特征，使人们能够更好地理解RNA在催化和蛋白质中的功能机制基础合成. 她目前的研究正在重塑关于金属离子在核酶功能中的作用的基础理论。 不再被视为严格的金属酶，一些核酶可以根据金属离子的身份和可用性来获得替代的催化机制。类似地，反应条件可以允许不同的折叠途径占主导地位，二价阳离子有时起相反的作用。