Biosynthesis of dibenzofurans

苹果和梨是重要的果树。火疫病和赤霉病的感染会造成产量的巨大损失。果树的植物保卫素是联苯和二苯并呋喃。联苯生物合成的步骤已在酶和基因水平上阐明，但二苯并呋喃的形成尚不清楚。推测的途径包括联苯2‘-羟基化和随后的环化。这些反应将使用激发子处理的组织培养进行生化研究，并使用比较转录组分析进行分子遗传学研究。

Apple and pear are important fruit trees. Infections by fire blight and scab cause dramatic losses in yield. The phytoalexins of the fruit trees are biphenyls and dibenzofurans. The steps of biphenyl biosynthesis were elucidated at the enzyme and gene levels, whereas the formation of dibenzofurans is still obscure. The postulated pathway involves biphenyl 2'-hydroxylation and subsequent cyclization. These reactions will be studied biochemically using elicitor-treated tissue cultures and molecular genetically using comparative transcriptome analysis.