Biosynthesis of dibenzofurans

二苯并呋喃的生物合成

• 批准号: 161900567
• 负责人: Professor Dr. Ludger Beerhues
• 金额: --
• 依托单位: Institut für Pharmazeutische Biologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/161900567?language=en
• 关键词: Biosynthesis; dibenzofurans

Apple and pear are important fruit trees. Infections by fire blight and scab cause dramatic losses in yield. The phytoalexins of the fruit trees are biphenyls and dibenzofurans. The steps of biphenyl biosynthesis were elucidated at the enzyme and gene levels, whereas the formation of dibenzofurans is still obscure. The postulated pathway involves biphenyl 2'-hydroxylation and subsequent cyclization. These reactions will be studied biochemically using elicitor-treated tissue cultures and molecular genetically using comparative transcriptome analysis.

苹果和梨是重要的果树。火疫病和疮痂病的感染造成产量的巨大损失。果树的植物抗毒素是联苯和二苯并呋喃。联苯生物合成的步骤已在酶和基因水平上阐明，而二苯并呋喃的形成仍然是模糊的。假定的途径涉及联苯2 '-羟基化和随后的环化。这些反应将使用激发子处理的组织培养物进行生化研究，并使用比较转录组分析进行分子遗传学研究。