SGER: Detection of Nucleic Acid Ligand Interactions on Microfabricated Surfaces

SGER：微加工表面上核酸配体相互作用的检测

• 批准号: 0303785
• 负责人: Andrew Ellington
• 金额: $ 10万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0303785&HistoricalAwards=false
• 关键词: SGER; Detection; Nucleic; Acid; Ligand

EIA-0303785 Andrew D. Ellington University of Texas- Austin Detection of Nucleic Acid Ligand Interactions on Microfabricated SurfacesBy putting effector-activated nucleic acid catalysts (aptazymes) on nanoscale mechanical and electronic devices, is allowing for a new paradigm for the integration of the biological world with electronic instrumentation. The aptazymes can sense a wide variety of analytes, such as metabolites, proteins, and even cell surfaces, and transduce the information directly to the mechanical or (ultimately) electronic devices. This most basic circuit for the transmogrification of biological and chemical information into electronic information should enable the construction of extremely novel devices not only for sensing, but also for actuation. Ultimately, these types of experiments will lead to a better integration of organismal physiology with instrumentation.

Andrew D.通过将效应物激活的核酸催化剂（适体酶）置于纳米级机械和电子设备上，允许生物世界与电子仪器集成的新范例。 适体酶可以检测各种各样的分析物，如代谢物，蛋白质，甚至细胞表面，并将信息直接传输到机械或（最终）电子设备。 这种将生物和化学信息转化为电子信息的最基本电路应该能够构建出极其新颖的设备，不仅用于传感，还用于驱动。 最终，这些类型的实验将导致生物生理学与仪器的更好整合。