SGER: Detection of Nucleic Acid Ligand Interactions on Microfabricated Surfaces

德克萨斯大学奥斯汀分校微加工表面上核酸配体相互作用的检测通过将效应活化的核酸催化剂（适配酶）放在纳米级机械和电子设备上，为生物世界与电子仪器的整合提供了一个新的范例。适配酶可以感知各种各样的分析物，如代谢物，蛋白质，甚至细胞表面，并将信息直接传递给机械或（最终）电子设备。这种将生物和化学信息转化为电子信息的最基本电路不仅可以用于传感，还可以用于驱动。最终，这些类型的实验将导致有机生理学与仪器更好的整合。

EIA-0303785 Andrew D. Ellington University of Texas- Austin Detection of Nucleic Acid Ligand Interactions on Microfabricated SurfacesBy putting effector-activated nucleic acid catalysts (aptazymes) on nanoscale mechanical and electronic devices, is allowing for a new paradigm for the integration of the biological world with electronic instrumentation. The aptazymes can sense a wide variety of analytes, such as metabolites, proteins, and even cell surfaces, and transduce the information directly to the mechanical or (ultimately) electronic devices. This most basic circuit for the transmogrification of biological and chemical information into electronic information should enable the construction of extremely novel devices not only for sensing, but also for actuation. Ultimately, these types of experiments will lead to a better integration of organismal physiology with instrumentation.