Isomeric Sugar Recognition Using Molecularly Imprinted Polymer Hydrogels

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AbstractProposal Title: Isomeric Sugar Recognition Using Molecularly Imprinted Polymer HydrogelsProposal Number: CTS-0303951Principal Investigator: Peter KofinasInstitution: University of MarylandThe objective of the proposed research is to prepare and test polymer hydrogels that have been molecularly imprinted with recognition properties for different materials. Molecularly imprinted polymers (MIP) will be synthesized and imprinted against specific simple sugar isomers. Methods will be developed for the detection and quantification of each molecular imprint. The MIP's total sugar binding, specificity, and rate of sugar diffusion will be evaluated in aqueous and physiological media. Specific sugar recognition will be optimized through combinatorial synthesis methods. A non-covalent approach to imprinting will be carried out in aqueous solution. Mechanistic studies will attempt to clarify the roles of molecular shape and functionality on selectivity. In terms of the broader impacts, novel MIPs might offer new avenues for biorecognition and isomeric separation techniques. The MIPs developed in this study may be used for bio-separations in conjunction with chromatographic techniques to separate amino acids, sugars, drugs, viruses and other bioactive compounds. In previous work K-12 activities have been developed. An interactive Website for K-12 will be developed in this project.