Isomeric Sugar Recognition Using Molecularly Imprinted Polymer Hydrogels

使用分子印迹聚合物水凝胶进行异构糖识别

• 批准号: 0303951
• 负责人: Peter Kofinas
• 金额: $ 25.62万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2007-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0303951&HistoricalAwards=false
• 关键词: Isomeric; Sugar; Recognition; Using; Molecularly

AbstractProposal Title: Isomeric Sugar Recognition Using Molecularly Imprinted Polymer HydrogelsProposal Number: CTS-0303951Principal Investigator: Peter KofinasInstitution: University of MarylandThe objective of the proposed research is to prepare and test polymer hydrogels that have been molecularly imprinted with recognition properties for different materials. Molecularly imprinted polymers (MIP) will be synthesized and imprinted against specific simple sugar isomers. Methods will be developed for the detection and quantification of each molecular imprint. The MIP's total sugar binding, specificity, and rate of sugar diffusion will be evaluated in aqueous and physiological media. Specific sugar recognition will be optimized through combinatorial synthesis methods. A non-covalent approach to imprinting will be carried out in aqueous solution. Mechanistic studies will attempt to clarify the roles of molecular shape and functionality on selectivity. In terms of the broader impacts, novel MIPs might offer new avenues for biorecognition and isomeric separation techniques. The MIPs developed in this study may be used for bio-separations in conjunction with chromatographic techniques to separate amino acids, sugars, drugs, viruses and other bioactive compounds. In previous work K-12 activities have been developed. An interactive Website for K-12 will be developed in this project.

摘要提案标题：使用分子印迹聚合物水凝胶识别异构糖提案编号：CTS-0303951主要研究员：Peter Kofinas机构： 马里兰大学拟议的研究的目的是制备和测试聚合物水凝胶已分子印迹识别性能的不同材料。 分子印迹聚合物（MIP）将被合成并针对特定的单糖异构体进行印迹。 将开发用于检测和定量每个分子印记的方法。 MIP的总糖结合、特异性和糖扩散速率将在水性和生理介质中进行评价。 将通过组合合成方法优化特定的糖识别。 印迹的非共价方法将在水溶液中进行。 机理研究将试图阐明分子形状和功能对选择性的作用。 就更广泛的影响而言，新型分子印迹聚合物可能为生物识别和异构体分离技术提供新的途径。 本研究开发的分子印迹聚合物可用于生物分离，结合色谱技术分离氨基酸，糖，药物，病毒和其他生物活性化合物。 在以前的工作中，已经开发了K-12活动。 本项目将为K-12开发一个互动网站。