NIRT: Rationally Designed Nanosensing Substrates for Chemical and Biodetection

EEC-0304097 William Marsh Rice UniversityHalas这个为期48个月的项目的目的是研究表面增强光谱作为纳米结构增强化学和生物检测的传感工具，重点是最小的样品制备和样品接触。 研究目标包括：（1）设计、构建和优化基于纳米结构的基底，用于基于表面等离子体共振光谱、表面增强拉曼光谱、荧光光谱和表面增强红外光谱的分子的超灵敏检测;（2）通过精确地模拟基底，发展对纳米结构增强化学检测的全面的基本理解，分子和近场在衬底-分子界面。以及（3）将这种基本理解应用于小分子、化学、生物和爆炸剂的特征官能团的化学检测，应用于蛋白质，并最终应用于微米尺寸的蛋白质涂覆的物体。

EEC-0304097William Marsh Rice UniversityHalasThe objective of this 48-month project is to investigate surface enhanced spectroscopy as a sensing tool for the nanostructure-enhanced chemical and biological detection, with a focus on minimal sample preparation and sample contact. The research goals include: (1) to design, construct and optimize nanostructure-based substrates for ultra sensitive detection of molecules based on Surface Plasmon Resonance Spectroscopy, Surface Enhanced Raman Spectroscopy, Fluorescence Spectroscopy, and Surface Enhanced Infrared Spectroscopy; (2) to develop a comprehensive fundamental understanding of nanostructure-enhanced chemical detection by accurately modeling the substrate, the molecule and the near field at the substrate-molecule interface., and (3) to apply this fundamental understanding to the chemical detection of small molecules, functional groups characteristic of chemical, biological and explosive agents, to proteins and ultimately to micron-sized protein-coated objects.