NIRT: Rationally Designed Nanosensing Substrates for Chemical and Biodetection

这个为期48个月的项目的目标是研究表面增强光谱作为纳米结构增强化学和生物检测的传感工具，重点是最小的样品制备和样品接触。研究目标包括：(1)设计、构建和优化基于表面等离子体共振光谱、表面增强拉曼光谱、荧光光谱和表面增强红外光谱的超灵敏分子检测纳米结构底物；(2)通过对底物、分子和底物-分子界面近场的精确建模，对纳米结构增强的化学检测有一个全面的基本理解。(3)将这一基本知识应用于小分子的化学检测，化学、生物和爆炸剂的官能团特征，蛋白质和最终微米大小的蛋白质涂层物体。

EEC-0304097William Marsh Rice UniversityHalasThe objective of this 48-month project is to investigate surface enhanced spectroscopy as a sensing tool for the nanostructure-enhanced chemical and biological detection, with a focus on minimal sample preparation and sample contact. The research goals include: (1) to design, construct and optimize nanostructure-based substrates for ultra sensitive detection of molecules based on Surface Plasmon Resonance Spectroscopy, Surface Enhanced Raman Spectroscopy, Fluorescence Spectroscopy, and Surface Enhanced Infrared Spectroscopy; (2) to develop a comprehensive fundamental understanding of nanostructure-enhanced chemical detection by accurately modeling the substrate, the molecule and the near field at the substrate-molecule interface., and (3) to apply this fundamental understanding to the chemical detection of small molecules, functional groups characteristic of chemical, biological and explosive agents, to proteins and ultimately to micron-sized protein-coated objects.