NIRT: Rationally Designed Nanosensing Substrates for Chemical and Biodetection

这个为期48个月的项目的目标是研究表面增强光谱学作为纳米结构增强的化学和生物检测的传感工具，重点是最小限度的样品制备和样品接触。研究目标包括：(1)设计、构建和优化基于表面等离子体共振光谱、表面增强拉曼光谱、荧光光谱和表面增强红外光谱的超灵敏分子检测的基于纳米结构的衬底；(2)通过对衬底、分子和衬底-分子界面的近场进行准确的建模，对纳米结构增强的化学检测有一个全面的基础了解；以及(3)将这一基础知识应用于对小分子、化学、生物和爆炸剂的官能团的化学检测，对蛋白质以及最终到微米大小的蛋白质涂层对象的化学检测。

EEC-0304097William Marsh Rice UniversityHalasThe objective of this 48-month project is to investigate surface enhanced spectroscopy as a sensing tool for the nanostructure-enhanced chemical and biological detection, with a focus on minimal sample preparation and sample contact. The research goals include: (1) to design, construct and optimize nanostructure-based substrates for ultra sensitive detection of molecules based on Surface Plasmon Resonance Spectroscopy, Surface Enhanced Raman Spectroscopy, Fluorescence Spectroscopy, and Surface Enhanced Infrared Spectroscopy; (2) to develop a comprehensive fundamental understanding of nanostructure-enhanced chemical detection by accurately modeling the substrate, the molecule and the near field at the substrate-molecule interface., and (3) to apply this fundamental understanding to the chemical detection of small molecules, functional groups characteristic of chemical, biological and explosive agents, to proteins and ultimately to micron-sized protein-coated objects.