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NER: Bottom-up Assembly of Nanomechanical Biosensing Arrays

NER：纳米机械生物传感阵列的自下而上组装

基本信息

批准号：
0304575
负责人：
Christine Keating
金额：
$ 10万
依托单位：
Pennsylvania State Univ University Park
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-01 至 2005-02-28
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0304575&HistoricalAwards=false
关键词：
NER Bottom up Assembly Nanomechanical

项目摘要

Professors Christine Keating and Theresa Mayer of Pennsylvania State University are supported by the Analytical and Surface Chemistry Program and the Nanotechnology Initiative to develop a novel biosensing strategy in which a nanomechanical transducer array is built from the bottom-up, by integrating nanobiosensor elements onto a CMOS chip. Sensing is accomplished by measuring a shift in the resonance frequency of nanowires due to the mass change associated with DNA hybridization. The DNA derivitization will guarantee high detection selectivity, while the nanometer scale dimensions of the resonant cantilevers will provide high sensitivity. This exploratory project will focus on the incorporation of DNA molecules onto the nanowires before alignment and integration and show that their bioactivity is retained, and sensitivity will be demonstrated. In addition to training graduate students in this collaborative environment between chemistry and chemical engineering, two undergraduates will also be involved as part of a Research Experience for Undergraduates Supplement. The project has the potential to impact several fields including trace detection and biosensing for food safety, national security, forensics and medical diagnostics. Introduction of the nanoscale in these applications is desired for low cost, rugged and miniaturized devices.

宾夕法尼亚州立大学的克莉丝汀教授和特蕾莎·迈耶教授得到了分析和表面化学项目以及纳米技术倡议的支持，他们开发了一种新的生物传感策略，通过将纳米生物传感器元件集成到CMOS芯片上，自下而上构建纳米机械传感器阵列。通过测量由于与DNA杂交相关的质量变化而引起的纳米线的共振频率的偏移来实现感测。 DNA衍生化将保证高检测选择性，而共振杠杆的纳米尺度尺寸将提供高灵敏度。该探索性项目将专注于在对齐和整合之前将DNA分子掺入纳米线上，并显示其生物活性得到保留，并将证明灵敏度。除了在化学和化学工程之间的这种合作环境中培养研究生外，两名本科生还将参与本科生补充研究经验的一部分。该项目有可能影响多个领域，包括食品安全、国家安全、法医学和医学诊断的痕量检测和生物传感。在这些应用中引入纳米尺度对于低成本、坚固耐用和小型化的设备来说是理想的。