Catalytic carbon-carbon bond breaking and forming methods

催化碳-碳键断裂和形成方法

• 批准号: 238524-2010
• 负责人: Fillion, Eric
• 金额: $ 4.44万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514381
• 关键词: Catalytic; carbon; bond; breaking; forming

The development of catalytic methods for the formation of carbon-carbon (C-C) sigma-bonds represents a challenging and dynamic area in organic chemistry. That unremitting interest is driven by the widespread appearance of such bonds in natural and non-natural bioactive compounds. Consequently, the expedient assembly and/or modification of C-C s bond-containing targets are of broad interest and demand the development of general chemo-, diastereo-, and enantioselective methods. Carbon-carbon bond formation has proven synthetic utility in the preparation of biologically active natural products, and plays a major role in medicinal chemistry and the development of pharmaceuticals.

用于形成碳-碳（C-C）σ键的催化方法的发展代表了有机化学中具有挑战性和动态的领域。这种不懈的兴趣是由这种键在天然和非天然生物活性化合物中的广泛出现所驱动的。因此，含有C-Cs键的靶标的便利组装和/或修饰具有广泛的兴趣，并且需要开发通用的化学选择性、非对映选择性和对映选择性方法。碳-碳键的形成在制备具有生物活性的天然产物中已被证明具有合成效用，并且在药物化学和药物开发中起着重要作用。