The neural correlates of social-communicative perception in patients with schizophrenia, major depression und bipolar disorder: Disorder specific and disorder-unspecific aspects of the comprehension, recognition and interpretation of verbal and non-verbal

精神分裂症（SZ）、抑郁症（MD）和双相情感障碍（BD）患者的特征是多模态语义和社会认知交际过程受损。这些功能障碍和相关神经相关性的疾病和综合征特异性和跨诊断价值是未知的。在拟议的项目中，社会交往功能的三个重要层面（参见Ochsner，2008; Biol. Psychiatry）将使用fMRI研究：1）非语言信息的理解，2）社会情感信息的识别和3）社会线索的解释。（DFG GZ：Ki 588/6-1），在精神分裂症患者中，我们可以表明偏执、混乱和阴性综合征与感知和社会情感脑区的激活特异性相关，Ochsners三种结构不同。到目前为止，所有数据都已收集和分析。已经发表了9篇经同行审查的研究文章，目前正在编写另外7份出版物。已完成四篇学士论文和两篇硕士论文。A.内格尔斯在该项目中担任博士后，他可以完成他的障碍和首席研究员B。Straube被任命为DFG Heisenberg-Professor。在拟议的项目中，将包括60名DSM IV SZ、MD、BD患者和健康对照受试者。通过SAPS / SANS、HAMD和YMRS进行综合征表征（偏执狂、紊乱、消极、躁狂、抑郁）。受试者将接受三种功能磁共振成像范式的检查，每种范式都反映了Ochsners的一个沟通水平。在范例中，使用了不同的视频剪辑，其中演员说话和手势。在第一个资助期内，这些视频已被设计、验证并用于SZ患者。延长第一个资助期，预计将产生疾病和综合征特异性和疾病非特异性效果。在分类诊断组中，我们预计1）阴性综合征与感知脑区域的激活减少相关，2）紊乱综合征与颞叶和前扣带皮层（ACC）活动相关，3）偏执综合征在解释社会线索时与ACC、后扣带皮层和双侧颞顶叶区域相关。抑郁和躁狂综合征预计与颞叶和边缘系统激活有关。该项目是第一个资助期的重要扩展，因为它1）验证了SZ患者的先前证据，它允许推断2）诊断特异性（SZ，MD，BD），3）诊断非特异性和4）关于社会沟通功能的综合征特异性结果。这些结果将为最相关的精神障碍和临床综合征提供新的病理生理学见解。

Patients with schizophrenia (SZ), major depression (MD) and bipolar disorder (BD) are characterized by impairments in multimodal semantic and socio-cognitive communicative processes. The disorder- and syndrome-specific and trans-diagnostic value of these dysfunctions and related neural correlates are unknown. In the proposed project three important levels of social communicative functioning (see Ochsner, 2008; Biol. Psychiatry) will be investigated using fMRI: 1) The comprehension of non-verbal information, 2) the recognition of social-affective information and 3) the interpretation of social cues.In the first funding period (DFG GZ: Ki 588/6-1), in patients with schizophrenia we could show that the paranoid, disorganized and negative syndrome was specifically associated with activation in perceptual and social-emotional brain regions, differentially for Ochsners three constructs. Until to date, all data have been acquired and analysed. Nine peer-reviewed research articles have already been published and seven additional publications are currently in preparation. Four bachelor- and two masters theses have been completed. A. Nagels, who worked as PostDoc in the project could finish his Habilitation and principal investigator B. Straube was appointed DFG Heisenberg-Professor.In the proposed project, 60 patients with DSM IV SZ, MD, BD and healthy control subjects will be included. By means of SAPS / SANS, HAMD and YMRS a syndromal characterisation will be performed (paranoid, disorganized, negative, manic, depressed). The subjects will be examined with three fMRI paradigms, each of which reflects one of Ochsners communication levels. In the paradigms different video clips, in which an actor speaks and gesticulates, are used. The videos have been designed, validated and used in patients with SZ during the first funding period.Extending the first funding period, disorder- and syndrome-specific and disorder-unspecific effects are expected. Across the categorical diagnostic groups we expect that 1) the negative syndrome correlates with reduced activation in perceptual brain regions, that 2) the disorganised syndrome correlates with temporal lobe and anterior cingulate cortex (ACC) activity and 3) the paranoid syndrome correlates during interpretation of social cues with ACC, posterior cingulate cortex and bilateral temporo-parietal regions. The depressive and manic syndrome are expected to be associated with temporal and limbic activations.This project is an important extension of the first funding period, since it 1) validates prior evidence for patients with SZ, it allows to infer 2) diagnosis specific (SZ, MD, BD), 3) diagnosis unspecific and 4) syndrome specific outcomes regarding social-communicative functioning. The results will provide a new pathophysiological insight onto the most relevant mental disorders and clinical syndromes.