Neural processes of social interaction in people with genetic and environmental risk factors for schizophrenia

具有精神分裂症遗传和环境危险因素的人社交互动的神经过程

• 批准号: 256835330
• 负责人: Professor Dr. Tilo Kircher
• 金额: --
• 依托单位: Klinik für Psychiatrie und Psychotherapie
• 依托单位国家: 德国
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/256835330?language=en
• 关键词: Neural; processes; social; interaction; people

Interpersonal collaboration, perspective taking (theory of mind) and empathy depends on the social/cultural identification with the interaction partner. Social categorization into ingoup (IG) and outgroup (OG), the resulting appreciation of the IG and the simultaneous devaluation of the OG has the potential for conflict at the societal level and constitutes a potential environmental risk factor (UR) for schizophrenia. Social categorization mediates behaviour during interaction. The neural processes and the interaction of these environmental factors with genetic risk (GR) for schizophrenia has not yet been explored.The influence of environmental (immigration status) and genetic risk factors (relatives of patients with schizophrenia) for schizophrenia on neural mirror neuron and Theory of Mind (ToM) networks will be investigated. Social interactions will be simulated between existing ethnic groups (germans vs. immigrants from Turkey) compared to fictitious groups (classified according to the minimal group paradigm: MGP), with high (GR +) and low genetic risk GR-), respectively. Thus, we intent to manipulate systematically two between-subject factors: genetic risk (GR + / GR-) and ethnicity (UR + / UR-) and two within-subject factors: MGP-manipulation of interaction partners (MGP-IG, MGP-OG) and ethnicity of the interaction partner (ethnicity-IG, ethnicity-OG). The neural correlates of these experimental manipulations are to be detected in the mirror neuron and ToM systems using functional magnetic resonance imaging (fMRI).We expect that the specific groups show enhanced empathy and perspective taking if the identification of the interaction partners is high (MPG-IG), he/she belongs to the same ethnic group (ethnicity-IG) and genetic risk is low (GR-). This will be reflected in the behavioural data as well as on neural level in increased activation in regions of the ToM and mirror neuron networks. It is hypothesised that subjects with genetic risk have reduced activation in ToM and mirror neuron networks (GR +

人际协作、观点采择（心理理论）和同理心取决于与互动伙伴的社会/文化认同。社会分类为内群体（IG）和外群体（OG），由此产生的IG的升值和OG的同时贬值有可能在社会层面上的冲突，并构成精神分裂症的潜在环境危险因素（UR）。社会分类在互动过程中调节行为。神经过程和这些环境因素与精神分裂症遗传风险（GR）的相互作用尚未被探索，精神分裂症的环境（移民身份）和遗传风险因素（精神分裂症患者的亲属）对神经镜像神经元和心理理论（ToM）网络的影响将被研究。将模拟现有种族群体（德国人与土耳其移民）与虚构群体（根据最小群体范式：MGP分类）之间的社会互动，分别具有高（GR +）和低遗传风险GR-）。因此，我们打算系统地操纵两个受试者之间的因素：遗传风险（GR + / GR-）和种族（UR + / UR-）和两个受试者内的因素：MGP操纵的相互作用的合作伙伴（MGP-IG，MGP-OG）和种族的相互作用的合作伙伴（种族-IG，种族-OG）。通过功能性磁共振成像（fMRI）在镜像神经元和ToM系统中检测这些实验操作的神经相关性，我们预计，如果互动伙伴的识别度高（MPG-IG），他/她属于同一种族（种族-IG），遗传风险低（GR-），特定群体表现出增强的同理心和观点采择。这将反映在行为数据中，以及在ToM和镜像神经元网络区域的激活增加的神经水平上。假设具有遗传风险的受试者在ToM和镜像神经元网络（GR +）中的激活减少