SFG Studies on Surface Structures of Polymethacrylates in Air, in Water, and Interacting with Protein Molecules

SFG 研究聚甲基丙烯酸酯在空气、水中以及与蛋白质分子相互作用的表面结构

• 批准号: 0315857
• 负责人: Zhan Chen
• 金额: $ 29.4万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0315857&HistoricalAwards=false
• 关键词: SFG; Studies; Surface; Structures; Polymethacrylates

Professor Zhan Chen of the University of Michigan is supported by the Analytical and Surface Chemistry Program to study polymer surfaces utilizing the nonlinear optical method sum frequency generation (SFG). Surface structures of poly(alkyl methacrylate) (PAMA) will be studied in water and in protein solutions. The study of polymer surface structures while in contact with protein molecules will elucidate how such surfaces mediate interactions between polymers and biological systems. Atomic force microscopy and contact angle methods will also be used to study the structures. For the students involved, the project combines training in analytical, material, surface and polymer sciences.The research will aid in establishing detailed relations between polymer surface structures and biocompatibility. The understanding can prove valuable to those designing materials that can reside and function in the body for long periods without fouling. Other applications include anticorrosion coatings and sensor development.

密歇根大学的Zhan Chen教授得到了分析和表面化学项目的支持，利用非线性光学方法和频产生（SFG）研究聚合物表面。 研究了聚甲基丙烯酸烷基酯（PAMA）在水和蛋白质溶液中的表面结构。 研究与蛋白质分子接触的聚合物表面结构将阐明这些表面如何介导聚合物与生物系统之间的相互作用。 原子力显微镜和接触角方法也将用于研究结构。 对于参与的学生，该项目结合了分析，材料，表面和聚合物科学的培训。该研究将有助于建立聚合物表面结构和生物相容性之间的详细关系。 这种理解对那些设计可以在体内长时间驻留和发挥作用而不结垢的材料是有价值的。 其他应用包括防腐蚀涂层和传感器开发。