Synthesis of Natural Productions: A systematic appraoch to Deoxysugars

天然产物的合成：脱氧糖的系统方法

• 批准号: 0316806
• 负责人: Peng Wang
• 金额: --
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316806&HistoricalAwards=false
• 关键词: Synthesis; Natural; Productions; systematic; appraoch

The focus of this research is in the development of synthetic methods for the synthesis of deoxysugars and glycosides from enantiomerically pure substituted beta,gamma-unsaturated delta-lactones. Using recently published methods involving olefin metathesis followed by epoxidation, the PI aims to provide highly efficient syntheses of a number of important deoxysugars of emerging biological importance, including 2,3,6-trideoxysugars, 2,6-dideoxysugars, 3-amino-2,3,6-trideoxysugars, 4,6-dideoxysugars, and some 6-deoxysugars. With this new award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Peng (George) Wang of the Department of Biochemistry at the Ohio State University, Columbus. Professor Wang will focus his research on the development of new ways to synthesize natural products bearing unusual sugar groups. This research will contribute to the fundamental understanding of the role these sugars have in biological activity. Biochemistry students at the graduate, undergraduate and post-doctoral level will be trained in Professor Wang's laboratory.

本研究的重点是开发从对映体纯的取代β，γ-不饱和δ-内酯合成脱氧糖和糖苷的合成方法。 使用最近公布的方法，涉及烯烃复分解，然后环氧化，PI的目的是提供一个新的生物重要性，包括2，3，6-三脱氧糖，2，6-双脱氧糖，3-氨基-2，3，6-三脱氧糖，4，6-双脱氧糖，和一些6-脱氧糖的一些重要的脱氧糖的高效合成。 凭借这一新奖项，有机和高分子化学项目正在支持位于哥伦布的俄亥俄州州立大学生物化学系的Peng（乔治）Wang博士的研究和教育工作。 王教授的研究重点是开发合成含有不寻常糖基的天然产物的新方法。 这项研究将有助于从根本上了解这些糖在生物活性中的作用。 王教授的实验室将培养研究生、本科生和博士后生物化学专业的学生。