Synthesis of Natural Productions: A systematic appraoch to Deoxysugars

天然产物的合成：脱氧糖的系统方法

• 批准号: 0316806
• 负责人: Peng Wang
• 金额: --
• 依托单位: Ohio State University Research Foundation -DO NOT USE
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316806&HistoricalAwards=false
• 关键词: Synthesis; Natural; Productions; systematic; appraoch

The focus of this research is in the development of synthetic methods for the synthesis of deoxysugars and glycosides from enantiomerically pure substituted beta,gamma-unsaturated delta-lactones. Using recently published methods involving olefin metathesis followed by epoxidation, the PI aims to provide highly efficient syntheses of a number of important deoxysugars of emerging biological importance, including 2,3,6-trideoxysugars, 2,6-dideoxysugars, 3-amino-2,3,6-trideoxysugars, 4,6-dideoxysugars, and some 6-deoxysugars. With this new award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Peng (George) Wang of the Department of Biochemistry at the Ohio State University, Columbus. Professor Wang will focus his research on the development of new ways to synthesize natural products bearing unusual sugar groups. This research will contribute to the fundamental understanding of the role these sugars have in biological activity. Biochemistry students at the graduate, undergraduate and post-doctoral level will be trained in Professor Wang's laboratory.

这项研究的重点在于开发合成方法，用于从对映体纯替代β，伽马不饱和的delta-lactones合成脱氧糖和糖苷的合成方法。 Using recently published methods involving olefin metathesis followed by epoxidation, the PI aims to provide highly efficient syntheses of a number of important deoxysugars of emerging biological importance, including 2,3,6-trideoxysugars, 2,6-dideoxysugars, 3-amino-2,3,6-trideoxysugars, 4,6-dideoxysugars, and some 6-deoxysugars. 有了这个新奖项，有机和大分子化学计划正在支持哥伦布俄亥俄州立大学生物化学系彭（George）Wang博士（George）Wang的研究和教育工作。 王教授将把他的研究集中在开发新方法的发展，以综合具有异常糖群的天然产品。 这项研究将有助于对这些糖在生物活性中的作用的基本理解。 毕业生，本科和博士后一级的生物化学学生将在王教授的实验室接受培训。