Synthesis of Natural Productions: A systematic appraoch to Deoxysugars

本研究的重点是开发以对映体纯取代β，伽马不饱和三角洲内酯为原料合成脱氧糖和糖苷的合成方法。利用最近发表的烯烃歧化和环氧化的方法，PI旨在提供一些具有重要生物学意义的重要脱氧糖的高效合成方法，包括2，3，6-三脱氧糖、2，6-二脱氧糖、3-氨基-2，3，6-三脱氧糖、4，6-二脱氧糖和一些6-脱氧糖。通过这个新的奖项，有机和高分子化学项目支持哥伦布市俄亥俄州立大学生物化学系的王鹏(George)博士的研究和教育努力。王教授将把研究重点放在开发合成含有不寻常糖基的天然产品的新方法上。这项研究将有助于从根本上理解这些糖在生物活性中的作用。生物化学研究生、本科生和博士后将在王教授的实验室接受培训。

The focus of this research is in the development of synthetic methods for the synthesis of deoxysugars and glycosides from enantiomerically pure substituted beta,gamma-unsaturated delta-lactones. Using recently published methods involving olefin metathesis followed by epoxidation, the PI aims to provide highly efficient syntheses of a number of important deoxysugars of emerging biological importance, including 2,3,6-trideoxysugars, 2,6-dideoxysugars, 3-amino-2,3,6-trideoxysugars, 4,6-dideoxysugars, and some 6-deoxysugars. With this new award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Peng (George) Wang of the Department of Biochemistry at the Ohio State University, Columbus. Professor Wang will focus his research on the development of new ways to synthesize natural products bearing unusual sugar groups. This research will contribute to the fundamental understanding of the role these sugars have in biological activity. Biochemistry students at the graduate, undergraduate and post-doctoral level will be trained in Professor Wang's laboratory.