Development of Green Chemistry for Syntheses of Polysaccharide-Based Materials

多糖基材料合成绿色化学的进展

• 批准号: 9728366
• 负责人: Peng Wang
• 金额: $ 18万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-10-01 至 2000-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9728366&HistoricalAwards=false
• 关键词: Development; Green; Chemistry; Syntheses; Polysaccharide

9728366 Wang The proposed research program uses renewable natural polysaccharides as a platform, and uses thermophilic enzyme libraries as a novel synthetic tool to develop environmentally friendly chemistry for the synthesis of novel po!ysaccharide-based materials. The major thrusts are the development and application of thermophilic enzyme catalysis. Extremozyme libraries from microorganisms in extreme environments (e.g. high temperature, high pressure or high salt concentration) constitute a new type of biocatalysts, which exhibit novel chemo-, regio- and stereo- selectivities and can be used at extremes of temperature or pH or in organic solvents in industrial processing. The specific aims and expected results for this program are: 1. Obtain a complete data base on glycosidase-catalyzed glycosylation with the thermophilic glycosidase library and synthesize a host of monosaccharide modified polysaccharide. 2. Utilize the thermophilic cellulase library to synthesize structurally well defined cellulose derivatives which can be used to study the structure/property relation of polysaccharides. 3. Develop thermophilic lipase/esterase-catalyzed polymerization technology to graft polyesters onto polysaccharides, and synthesize a host of novel polysaccharide-polyester materials. This program will serve to demonstrate and promote the use of environmentally friendly biocatalysis to transform renewable natural resources into novel materials. ***

9728366 WANG提出的研究计划使用可再生的天然多糖作为平台，并使用嗜热酶库作为一种新型的合成工具来开发环保化学，以合成新型PO！ysacCharide基材料。 主要的推力是嗜热酶催化的开发和应用。 极端环境（例如高温，高压或高盐浓度）中微生物的极端生物文库构成了一种新型的生物催化剂，它们表现出新型的化学化学，区域性和立体选择性，并且可以在工业处理中的有机溶剂中在极端或温度或pH值中使用。 该程序的具体目的和预期结果是：1。用嗜热糖苷酶文库获得糖苷酶催化的糖基化的完整数据库，并合成大量单糖修饰的多糖糖。 2。利用嗜热纤维酶文库合成结构良好的纤维素衍生物，可用于研究多糖的结构/性质关系。 3。开发嗜热脂肪酶/酯酶催化的聚合技术，以将聚酯移植到多糖上，并合成大量新型的多糖酸酯材料。 该计划将有助于演示和促进环保生物催化的使用，以将可再生自然资源转化为新型材料。 ***