Development of Green Chemistry for Syntheses of Polysaccharide-Based Materials

多糖基材料合成绿色化学的进展

• 批准号: 9728366
• 负责人: Peng Wang
• 金额: $ 18万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-10-01 至 2000-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9728366&HistoricalAwards=false
• 关键词: Development; Green; Chemistry; Syntheses; Polysaccharide

9728366 Wang The proposed research program uses renewable natural polysaccharides as a platform, and uses thermophilic enzyme libraries as a novel synthetic tool to develop environmentally friendly chemistry for the synthesis of novel po!ysaccharide-based materials. The major thrusts are the development and application of thermophilic enzyme catalysis. Extremozyme libraries from microorganisms in extreme environments (e.g. high temperature, high pressure or high salt concentration) constitute a new type of biocatalysts, which exhibit novel chemo-, regio- and stereo- selectivities and can be used at extremes of temperature or pH or in organic solvents in industrial processing. The specific aims and expected results for this program are: 1. Obtain a complete data base on glycosidase-catalyzed glycosylation with the thermophilic glycosidase library and synthesize a host of monosaccharide modified polysaccharide. 2. Utilize the thermophilic cellulase library to synthesize structurally well defined cellulose derivatives which can be used to study the structure/property relation of polysaccharides. 3. Develop thermophilic lipase/esterase-catalyzed polymerization technology to graft polyesters onto polysaccharides, and synthesize a host of novel polysaccharide-polyester materials. This program will serve to demonstrate and promote the use of environmentally friendly biocatalysis to transform renewable natural resources into novel materials. ***

9728366 Wang拟议的研究计划以可再生天然多糖为平台，以嗜热酶库为新型合成工具，开发用于合成新型多糖的环保化学！依斯替林基材料。 其主要发展方向是嗜热酶催化技术的开发和应用。 极端酶文库是一种新型的生物催化剂，具有独特的化学选择性、区域选择性和立体选择性，可以在极端温度、pH值或有机溶剂条件下进行工业化生产。 该方案的具体目标和预期成果是： 1.利用嗜热糖苷酶库获得了完整的糖苷酶催化糖基化数据库，并合成了大量单糖修饰的多糖。 2.利用嗜热纤维素酶库合成结构明确的纤维素衍生物，可用于研究多糖的结构/性质关系。 3.开发了嗜热脂肪酶/酯酶催化聚合技术，将聚酯接枝到多糖上，合成了一系列新型多糖-聚酯材料。 该计划将用于展示和推广使用环保生物催化将可再生自然资源转化为新材料。 ***