SBIR Phase II: Urea Sensing Biocatalytic Polymers

该小型企业创新研究第二阶段项目提出开发基于酶聚合和化学传感技术的尿液检测原型产品，用于养老院，日托机构和医疗保健机构。这些产品将包括手持式传感器、海绵擦拭物和暴露于尿液后会变色的床上用品织物垫。传感器配方中使用的酶的严格特异性将为传感装置提供快速响应时间和高精度，从而限制假阳性和阴性信号。在第一阶段的概念验证之后，第二阶段的传感器优化工作将集中在信号增强、用于定量分析的多组分传感器的开发以及改进拟议传感产品的可用性和操作保质期。该项目的商业应用将广泛应用于各种公共设施，包括医院、疗养院、日托中心和食品/招待机构。

This Small Business Innovation Research Phase II project proposes to develop prototype urine-detecting products based on enzyme-polymerization and chemical sensing technologies for use in nursing homes, daycare establishments and healthcare facilities. These products will include hand-held sensors, sponge wipes, and bedding fabric pads that change color upon exposure to urine. The strict specificity of the enzymes used in sensor formulation will provide the sensing devices with rapid response times and great precision, thus limiting false positive and negative signals. Having shown the proof of concept in Phase I , the sensor optimization work in this Phase II project will focus on signal enhancement, the development of multi-component sensors for quantitative analysis, and improvements in the usability and the operational shelf life of the proposed sensing products.The commercial application of this project will be for a broad range of public facilities, including hospitals, nursing homes, daycare centers and food / hospitality establishments.