Workshop: The Roles of Mathematics and Computation in Systems and Integrative Biology, USU Campus, Logan, Utah, Spring 2003

研讨会:数学和计算在系统和综合生物学中的作用,USU 校园,犹他州洛根,2003 年春季

基本信息

  • 批准号:
    0321567
  • 负责人:
  • 金额:
    $ 3.41万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-04-01 至 2004-03-31
  • 项目状态:
    已结题

项目摘要

The Roles of Mathematics and Computation in Systems and Integrative BiologyAt both the large (population, community, ecosystem) and small scales (chemical and chromosomal) quantitative techniques are widely acknowledged to be useful in answering biological questions. Arguably, these efforts have produced interesting mathematics, statistics, and quantitative advances. However, at scales larger than DNA but smaller than populations, the biological and mathematical communities have failed to take full advantage of one another. In systems or integrative biology this failure is particularly telling. Systems biology is primarily concerned with how biological components interact to produce adaptive behavior at a larger scale of integration. We interpret systems biology broadly to encompass areas such as intracellular genetic and protein network dynamics during development, integration of tissue responses to create dynamic homeostasis at the organism level, the emergence of higher cognitive function from neural networks, as well as the organization of social systems by the movement and interaction of individual organisms. Such questions can clearly benefit from advances in mathematical, statistical, computational, and engineering analysis. There are several reasons for enhancing the mathematical and computational components of systems biology. As a positive benefit, since there have been many scientific payoffs in genomics, bioinformatics and environmental biology, which have largely embraced quantitative methodology, it seems natural to investigate what similar opportunities exist in systems biology and what key issues need to be addressed to achieve these opportunities. A second reason is that the increased successful emphasis on mathematical and computational approaches in competing disciplines such as medicine, genomics, and proteomics, will reduce funding opportunities for systems biology if it does not also embrace these analytical methods. An opportunity for deeper understanding of integrated living systems may be lost if we fail to exploit advances in the mathematical and computational sciences. We propose to organize a small workshop to help chart how mathematical, statistical and computational methods are most likely to be useful in integrative or systems biology, what stumbling blocks exist, and how to motivate increased utilization of quantitative methods and participation of mathematical and computational specialists in biology at these neglected scales. Through directed discussion among a group of leading researchers and educators, the workshop will i) identify the most effective ways that quantitative analysis can fundamentally enhance research and education in Integrative Biology, ii) identify immediate and long-term educational needs [requirements] for developing those multidisciplinary skills that will facilitate the future use of quantitative approaches in Integrative Biology, and iii) outline goals and strategies to support increased use of quantitative methods in systems biology at these neglected scales.What is the intellectual merit of the proposed activity? The workshop is organized to address pressing questions on the multidisciplinary use of quantitative methodologies in systems-level biology: how may such approaches most fruitfully be used, are all the keystone pieces in place for their use, and what technologies and training must be developed to fully utilize these technologies? By examining these questions and proposing answers it is hoped that the workshop will facilitate a whole new vein of scientific breakthroughs.What are the broader impacts of the proposed activity? Systems biology, by its nature, is integrative and serves to increase understanding of relationships among smaller-scale systems. Particularly when enhanced with models, such understandings tend to systematize knowledge, therefore aiding with general instruction and education. More specifically, one of the objectives of the workshop is to discuss what training is necessary to facilitate advancing the role of mathematics and computation in integrative biology. This is likely to involve educational issues at all levels in all fields involved: biology, math, statistics, computer science, and engineering.
数学和计算在系统和综合生物学中的作用在大尺度(种群、群落、生态系统)和小尺度(化学和染色体)上,定量技术被广泛认为在回答生物学问题上是有用的。可以说,这些努力产生了有趣的数学,统计和定量进步。 然而,在比DNA更大但比种群更小的尺度上,生物学和数学界未能充分利用彼此。 在系统或整合生物学中,这种失败尤其明显。 系统生物学主要关注生物成分如何相互作用,以在更大规模的整合中产生适应行为。我们将系统生物学广泛地解释为包括以下领域:发育过程中的细胞内遗传和蛋白质网络动态,组织反应的整合以在生物体水平上创建动态稳态,神经网络中更高认知功能的出现,以及通过个体生物体的运动和相互作用组织社会系统。 这些问题显然可以从数学、统计、计算和工程分析的进步中受益。 增强系统生物学的数学和计算成分有几个原因。 作为一个积极的好处,因为有许多 由于基因组学、生物信息学和环境生物学在很大程度上采用了定量方法,因此,调查系统生物学中存在哪些类似的机会,以及需要解决哪些关键问题才能实现这些机会,似乎是很自然的。 第二个原因是,在医学、基因组学和蛋白质组学等相互竞争的学科中,越来越多的人成功地强调数学和计算方法,如果系统生物学不接受这些分析方法,它将减少资助机会。 如果我们不能利用数学和计算科学的进步,就可能失去更深入地了解综合生命系统的机会。 我们建议组织一个小型研讨会,以帮助图表如何数学,统计和计算方法是最有可能是有用的综合或系统生物学,存在什么绊脚石,以及如何激励更多的利用定量方法和参与的数学和计算专家在生物学在这些被忽视的尺度。 通过一组领先的研究人员和教育工作者之间的直接讨论,研讨会将i)确定定量分析可以从根本上加强综合生物学研究和教育的最有效方法,ii)确定发展这些多学科技能的直接和长期教育需求[要求] 这将有助于未来在综合生物学中使用定量方法,iii)概述目标和策略,以支持在这些被忽视的尺度上增加系统生物学中定量方法的使用。 该研讨会的组织,以解决紧迫的问题,在系统级生物学的定量方法的多学科使用:如何才能最富有成效地使用这种方法,所有的基石,为他们的使用,以及必须开发什么技术和培训,以充分利用这些技术? 通过研究这些问题并提出答案,希望研讨会将促进一个全新的科学突破思路。拟议活动的更广泛影响是什么? 系统生物学,就其本质而言,是综合性的,有助于增加对小规模系统之间关系的理解。 特别是当用模型增强时,这种理解往往会使知识系统化,从而有助于一般的指导和教育。 更具体地说,研讨会的目标之一是讨论什么样的培训是必要的,以促进推进数学和计算在综合生物学中的作用。 这可能涉及所有相关领域的各个层面的教育问题:生物学、数学、统计学、计算机科学和工程学。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

James Powell其他文献

Human-in-the-Loop Refinement of Word Embeddings
词嵌入的人在环优化
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    James Powell;Kari Sentz;Martin Klein
  • 通讯作者:
    Martin Klein
Phase transition from environmental to dynamic determinism in mountain pine beetle attack
  • DOI:
    10.1007/bf02458422
  • 发表时间:
    1997-07-01
  • 期刊:
  • 影响因子:
    2.200
  • 作者:
    Peter White;James Powell
  • 通讯作者:
    James Powell
Compendium of Animal Rabies Prevention and Control, 2011* National Association of State Public Health Veterinarians, Inc. (NASPHV)
动物狂犬病预防和控制纲要,2011 年* 国家公共卫生兽医协会 (NASPHV)
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Catherine M. Brown;D. Gatewood;Barbara Nay;Raoult C Ratard;Charles E. Rupprecht;D. Slate;James Powell
  • 通讯作者:
    James Powell
Patient Involvement in the Design of a Randomised Trial of Proton Beam Radiotherapy Versus Standard Radiotherapy for Good Prognosis Glioma.
患者参与质子束放射治疗与标准放射治疗治疗胶质瘤良好预后的随机试验的设计。
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    James Powell;Louise Murray;Neil G. Burnet;S. Fernandez;Z. Lingard;L. McParland;Daniel O’Hara;Gillian A Whitfield;Susan C Short
  • 通讯作者:
    Susan C Short
Members of the Editorial Committee
编委会成员
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Dave Longworth;Allan Crawford;P. Fenton;P. Godin;Clyde Goodlet;D. Howard;K. Mcphail;Philippe Muller;J. Murray;G. Pickering;James Powell;C. Ragan;Denis Schuthe;Bonnie Schwab;Jack Selody;Robert J. Turnbull;Mark Zelmer;E. Cave;J. Moxley;Lea
  • 通讯作者:
    Lea

James Powell的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('James Powell', 18)}}的其他基金

Belmont Forum Collaborative Research: AWERRS Arctic Wetlands Ecosystems – Resilience through Restoration & Stewardship
贝尔蒙特论坛合作研究:AWERRS 北极湿地生态系统 — 通过恢复实现恢复力
  • 批准号:
    2114864
  • 财政年份:
    2021
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
NNA Track 1: Collaborative Research: Navigating Impacts of the Arctic Tourism Industry on Nature, Commerce, and Culture in Northern Communities
NNA 轨道 1:合作研究:探讨北极旅游业对北部社区自然、商业和文化的影响
  • 批准号:
    2022699
  • 财政年份:
    2020
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
RAPID: Collaborative Research: Local Government Response to COVID-19: Juneau Alaska, a case study in adaptive governance, risk management, communication, and decision-making
RAPID:协作研究:地方政府对 COVID-19 的反应:朱诺阿拉斯加,适应性治理、风险管理、沟通和决策的案例研究
  • 批准号:
    2028928
  • 财政年份:
    2020
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
NNA Track 1: Collaborative Research: Arctic Urban Risks and Adaptations (AURA): a co-production framework for addressing multiple changing environmental hazards
NNA 第 1 轨道:合作研究:北极城市风险与适应 (AURA):解决多种不断变化的环境危害的联合生产框架
  • 批准号:
    1927312
  • 财政年份:
    2019
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
Collaborative Research: Bridging Math and Science - Authentic Laboratory Experiences in Mathematical Biology
合作研究:连接数学和科学 - 数学生物学的真实实验室经验
  • 批准号:
    1245421
  • 财政年份:
    2013
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
Homogenization Applied to Integrate Across Spatial and Temporal Scales in Forest/Insect Ecology
均质化应用于森林/昆虫生态学中时空尺度的整合
  • 批准号:
    0077663
  • 财政年份:
    2000
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
U.S.-Netherlands Cooperative Research: International Collaboration on Modeling Biocontrol of Botrytis Pathogens
美国-荷兰合作研究:灰霉病病原体生物防治建模国际合作
  • 批准号:
    9813421
  • 财政年份:
    1999
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
Acquisition of a High-Performance Computer for Mathematical Sciences Applications
采购用于数学科学应用的高性能计算机
  • 批准号:
    9724245
  • 财政年份:
    1997
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
Mathematical Sciences: Nonlinear Self-focussing as a Deterministic Mechanism for Generating Spatial Complexity in Ecosystems
数学科学:非线性自聚焦作为生态系统中产生空间复杂性的确定性机制
  • 批准号:
    9505327
  • 财政年份:
    1995
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
Pairwise Difference Estiamtion in Econometrics
计量经济学中的成对差分估计
  • 批准号:
    9210101
  • 财政年份:
    1992
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Continuing Grant

相似海外基金

Collaborative Research: Subduction Megathrust Rheology: The Combined Roles of On- and Off-Fault Processes in Controlling Fault Slip Behavior
合作研究:俯冲巨型逆断层流变学:断层上和断层外过程在控制断层滑动行为中的综合作用
  • 批准号:
    2319848
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
Collaborative Research: Subduction Megathrust Rheology: The Combined Roles of On- and Off-Fault Processes in Controlling Fault Slip Behavior
合作研究:俯冲巨型逆断层流变学:断层上和断层外过程在控制断层滑动行为中的综合作用
  • 批准号:
    2319849
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
Chemical staples and chemical probes to dissect dynamins cellular roles.
用于剖析动力细胞作用的化学钉书和化学探针。
  • 批准号:
    DP240100514
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Discovery Projects
A genome wide investigation into the roles of error-prone polymerases during human DNA replication
对易错聚合酶在人类 DNA 复制过程中的作用进行全基因组研究
  • 批准号:
    24K18094
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Roles of immune cells derived from clonal hematopoiesis in B-cell lymphomas
克隆造血来源的免疫细胞在 B 细胞淋巴瘤中的作用
  • 批准号:
    24K19213
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
BeyondSNO: Signalling beyond protein S-nitrosylation - determining the roles of nitroxyl and hydroxylamine
BeyondSNO:蛋白质 S-亚硝基化之外的信号传导 - 确定硝酰基和羟胺的作用
  • 批准号:
    EP/Y027698/1
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Research Grant
Roles of emerging pollutants in spreading antimicrobial resistance
新出现的污染物在传播抗菌素耐药性方面的作用
  • 批准号:
    DE240100842
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Discovery Early Career Researcher Award
Uncovering the unconventional and multifaceted roles of histamine in bacterial infection
揭示组胺在细菌感染中的非常规和多方面的作用
  • 批准号:
    502559
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
Collaborative Research: Subduction Megathrust Rheology: The Combined Roles of On- and Off-Fault Processes in Controlling Fault Slip Behavior
合作研究:俯冲巨型逆断层流变学:断层上和断层外过程在控制断层滑动行为中的综合作用
  • 批准号:
    2319850
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
Two-Dimensional Magnets in Spintronic Devices: Roles of Spin Fluctuations
自旋电子器件中的二维磁体:自旋涨落的作用
  • 批准号:
    2401267
  • 财政年份:
    2024
  • 资助金额:
    $ 3.41万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了