SGER: A New Interfacial Free-Radical Polymerization Approach for Direct Hollow Capsule Encapsulation

SGER：一种用于直接空心胶囊封装的新型界面自由基聚合方法

• 批准号: 0324303
• 负责人: Carlos Co
• 金额: --
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0324303&HistoricalAwards=false
• 关键词: SGER; New; Interfacial; Free; Radical

ABSTRACTPI: Carlos Co Institution: University of CincinnatiProposal Number: 0324303Intellectual Merit:This SGER project is exploratory research on an interfacial free-radical polymerization approach for the direct encapsulation of substrates in hollow capsules with nanometer thick polymer shells. This approach relies on the interfacial alternating copolymerization of maleate and vinyl ether monomers. By choosing hydrophobic and hydrophilic combinations of these two monomer types, which individually do not homopolymerize, the polymeriztion is constrained to occur only at oil/water interfaces. The principles and methodology behind this encapsulation technique, if proven, will allow for the direct encapsulation of many substrates through a scalabale, inexpensive process presenting a high degree of flexibility and control in manipulating the shell thickness, permeability, and surface chemistry.Broad Impact:This process, which potentially combines the best features of existing hollow encapsulation technologies, could have widespread and immediate applications in the encapsulation and controlled release of many drugs, dyes, cells, enzymes, transfection vectors, etc. In addition, the general principle of interfacial free-radical alternating copolymerziation has many potential applications extending beyond hollow-capsule encapsulation and into many established nanotechnologies where the preponderance of interfaces accentuates the significance of this polymerization technique. The project will also serve to educate and train undergraduate and graduate students in the principles of interfacial phenomena and radical polymerizations.

摘要PI：Carlos CO机构：辛辛那提大学的编号：0324303Intlectual Furet：该SGER项目是对界面自由基聚合方法的探索性研究，用于直接用氮气厚度聚合物壳直接封装空心胶囊中的底物。 这种方法依赖于Maleate和乙烯基醚单体的界面交替共聚。 通过选择这两种单体类型的疏水和亲水性组合，它们单独地不均聚合，聚合物的聚合物仅在油/水接口处发生。 这种封装技术背后的原理和方法（如果得到证明）将允许通过斜角，廉价的过程直接封装许多底物，从而表现出高度的灵活性和控制壳的厚度，渗透率和表面化学的控制。此外，许多药物，染料，细胞，酶，转染载体等。此外，界面自由基交流共聚物的一般原理具有许多潜在的应用，这些应用范围延伸到空心封装之外，并延伸到许多已建立的纳米技术中，其中界面的界限均能使这种构成技术的重要性。 该项目还将有助于教育和培训本科生和研究生，了解界面现象和激进聚合的原则。