SGER: A New Interfacial Free-Radical Polymerization Approach for Direct Hollow Capsule Encapsulation

简介：卡洛斯公司：辛辛那提大学建议编号：0324303智力优点：这个SGER项目是对界面自由基聚合方法的探索性研究，这种方法直接将基质包裹在带有纳米厚聚合物壳的中空胶囊中。这种方法依赖于马来酸酯和乙烯基醚单体的界面交替共聚。通过选择这两种单体类型的疏水和亲水组合，分别不进行均聚合，聚合被限制为仅在油/水界面发生。这种封装技术背后的原理和方法如果得到验证，将允许通过大规模、廉价的工艺直接对许多底物进行封装，在控制壳层厚度、渗透性和表面化学方面表现出高度的灵活性和可控性。广泛的影响：该工艺潜在地结合了现有中空封装技术的最佳特征，可以在许多药物、染料、细胞、酶、转染剂等的封装和受控释放中具有广泛和即时的应用。此外，界面自由基交替共聚的一般原理有许多潜在的应用，不仅是中空胶囊的封装，还包括许多成熟的纳米技术，其中界面的优势突出了这种聚合技术的重要性。该项目还将对本科生和研究生进行界面现象和自由基聚合原理方面的教育和培训。

ABSTRACTPI: Carlos Co Institution: University of CincinnatiProposal Number: 0324303Intellectual Merit:This SGER project is exploratory research on an interfacial free-radical polymerization approach for the direct encapsulation of substrates in hollow capsules with nanometer thick polymer shells. This approach relies on the interfacial alternating copolymerization of maleate and vinyl ether monomers. By choosing hydrophobic and hydrophilic combinations of these two monomer types, which individually do not homopolymerize, the polymeriztion is constrained to occur only at oil/water interfaces. The principles and methodology behind this encapsulation technique, if proven, will allow for the direct encapsulation of many substrates through a scalabale, inexpensive process presenting a high degree of flexibility and control in manipulating the shell thickness, permeability, and surface chemistry.Broad Impact:This process, which potentially combines the best features of existing hollow encapsulation technologies, could have widespread and immediate applications in the encapsulation and controlled release of many drugs, dyes, cells, enzymes, transfection vectors, etc. In addition, the general principle of interfacial free-radical alternating copolymerziation has many potential applications extending beyond hollow-capsule encapsulation and into many established nanotechnologies where the preponderance of interfaces accentuates the significance of this polymerization technique. The project will also serve to educate and train undergraduate and graduate students in the principles of interfacial phenomena and radical polymerizations.