Neuro Imaging through Internet2

西奈山医学院(MSSM)寻求资助Abilene/Internet2，以更好地处理图像分析和处理的需求。最近，国家研究资源中心(NCRR)拨款允许该机构升级主要研究大楼的计算机网络。广域网络现在成为与其他机构合作的瓶颈。这一连接本身还将支持下列领域的合作项目：哺乳动物神经元的三维形态计量分析：MSSM、库兰特数学科学研究所(NYU)、纽约大学医学院、纽约州立大学石溪分校和澳大利亚新南威尔士大学的研究人员之间的合作。MSSM的研究人员使用先进的3D显微成像技术以及3D图像处理、渲染、分析和建模来研究大脑中神经元的结构和功能关系。CNIC的研究人员正在使用共焦显微镜和多光子显微镜以尽可能高的分辨率对皮质中的整个锥体神经元进行(3D)成像。这为单个神经元创建了大约20 GB的数据集。收集数据后，将其输出到计算机，在计算机上进行图像拼接、体绘制、反卷积和3D图像分析。该奖项将极大地促进非现场合作者访问这些大型数据集的能力，以及使用由CNIC调查人员开发并托管在MSSM的独特软件来操纵和分析数据的能力。前庭功能的神经机制：华盛顿大学、犹他大学和NASA-Ames的MSSM研究人员和合作者正在研究前庭功能。正在进行电生理学和显微镜研究，以确定前庭感觉上皮传入反应动力学的区域性差异的基础。600 MB到1.2 GB的数据集是使用多照片激光创建的。通过访问MSSM计算机上托管的体积绘制和3D图像分析软件来处理3D数据的能力将为非现场合作者提供宝贵的信息。此外，由于编辑任何一项实验的数据所需的时间长度，合作者在多光子显微镜上(实时)收集数据时审查数据将是非常有益的。这将避免反馈中的任何延迟，并允许场外合作者修改实验条件。

Mount Sinai School of Medicine (MSSM) seeks funding for an Abilene/Internet2 to better handle the demands of image analysis and processing. A recent National Center for Research Resources (NCRR) grant allowed the institution to upgrade the computer network in the main research building. The wide area network now presents a bottleneck for collaboration with other institutions. The connection, itself, will also support collaborative projects in the following areas: 3-dimensional Morphometric Analysis of Mammalian Neurons: A collaboration between MSSM, investigators from the Courant Institute of Mathematical Sciences (NYU), New York University School of Medicine, SUNY at Stony Brook, and the University of New South Wales, Australia. Researchers at MSSM study the structure-function relationship of neurons in the brain, employing advanced 3D microscopic imaging techniques as well as 3D image processing, rendering, analysis and modeling. CNIC investigators are using confocal and multi-photon microscopes to image (in 3D) entire pyramidal neurons in the cortex at the highest resolution possible. This creates approximately 20-gigabyte data sets for a single neuron. After the data is collected, it is exported to computers, where image stitching, volume rendering, deconvolution and 3D-image analysis is done. This award will greatly facilitate the capabilities of off-site collaborators to access these large datasets as well as manipulate and analyze the data using unique software developed by CNIC investigators and hosted at MSSM. Neural Mechanisms of Vestibular Function: MSSM researchers and collaborators at Washington University, the University of Utah and NASA-Ames are studying vestibular functions. Electrophysiological and microscopic studies are being performed to determine the basis for regional variations in afferent response dynamics across the vestibular sensory epithelium. 600 Mbytes to 1.2-gigabyte data sets are created using a multi-photo laser. The ability to manipulate the data in 3D via access to volume rendering and 3D image analysis software hosted on MSSM computers will provide invaluable information to off-site collaborators. Furthermore, due to the length of time required to compile the data for any one experiment, it will be greatly beneficial for collaborators to review the data as it is collected (in real time) on the multi-photon microscope. This will avoid any delay in feedback and permit the off-site collaborators to modify experimental conditions.