Mechanisms of cell death regulation by the Bcl-2 protein family

Bcl-2蛋白家族调节细胞死亡的机制

• 批准号: DP0988616
• 负责人: A/Prof Erinna Lee
• 金额: --
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0988616
• 关键词: Mechanisms; cell; death; regulation; Bcl

Through the proposed study, the expected outcome is a better understanding of the important process of how the Bcl-2 family of proteins interact with each to control cell death. Furthermore, as dysfunctional apoptosis signalling contributes to diseases such as autoimmune conditions, neurodegenerative disorders and cancer, a detailed and sound understanding of how the cell death machinery operates should enable the design of more effective and importantly, safer therapies against these pathologies.

通过拟议的研究，预期的结果是更好地了解Bcl-2蛋白家族如何相互作用以控制细胞死亡的重要过程。此外，由于功能失调的细胞凋亡信号传导有助于疾病，如自身免疫性疾病，神经退行性疾病和癌症，对细胞死亡机制如何运作的详细和合理的理解应该能够设计出更有效，更重要的是，更安全的治疗方法来对抗这些病理。