Mechanisms by which Beclin1 regulates intestinal homeostasis

Beclin1 调节肠道稳态的机制

• 批准号: DP190102612
• 负责人: A/Prof Erinna Lee
• 金额: $ 28.03万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-10-21 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102612
• 关键词: Mechanisms; Beclin1; regulates; intestinal; homeostasis

This project aims to investigate if Beclin1, a protein which has an important and well-accepted role in promoting cell survival through the program of autophagy, has an alternate job mediating trafficking within a cell. Using novel mouse models and innovative techniques, the project aims to demonstrate the physiological importance of this alternate role for Beclin1. Expected outcomes include enhancing Australia's international research standing, and providing research training for young scientists. Benefits include generation of new knowledge and a rethink of the basis for normal development and diseases where Beclin1 has been implicated.

该项目旨在研究Beclin 1，一种通过自噬程序在促进细胞存活方面具有重要和公认作用的蛋白质，是否具有介导细胞内运输的替代工作。该项目使用新型小鼠模型和创新技术，旨在证明Beclin1这种替代作用的生理重要性。预期成果包括提高澳大利亚的国际研究地位，并为青年科学家提供研究培训。好处包括产生新的知识和重新思考正常发育和Beclin1相关疾病的基础。