Crosstalk between cell survival and cell death pathways

细胞存活和细胞死亡途径之间的串扰

• 批准号: FT150100212
• 负责人: A/Prof Erinna Lee
• 金额: $ 49.48万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT150100212
• 关键词: Crosstalk; between; cell; survival; death

This project aims to determine the precise molecular mechanisms underlying cell fate decisions. The dynamics between cell survival (autophagy) and cell death (apoptosis) are complex, involving significant crosstalk between these pathways. This is fundamentally important to cellular processes. Aberrant control of autophagy and apoptosis affects the function of all organisms as well as the development and treatment of diseases ranging from cancer to heart disease. This project endeavours to advance our understanding of the proteins that interconnect autophagy and apoptosis. The results are expected to explain how cells determine their fate and inform future development of strategies to treat disease.

该项目旨在确定细胞命运决定的精确分子机制。细胞存活（自噬）和细胞死亡（凋亡）之间的动力学是复杂的，涉及这些途径之间的显著串扰。这对细胞过程至关重要。自噬和凋亡的异常控制影响所有生物体的功能以及从癌症到心脏病的疾病的发展和治疗。该项目致力于推进我们对自噬和凋亡相互关联的蛋白质的理解。这些结果有望解释细胞如何决定它们的命运，并为未来治疗疾病的策略提供信息。