SBIR Phase I: Portable SI-HPLC Analyzer

SBIR 第一阶段：便携式 SI-HPLC 分析仪

• 批准号: 0340181
• 负责人: Garth Klein
• 金额: $ 10万
• 依托单位: FIAsolutions
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0340181&HistoricalAwards=false
• 关键词: SBIR; Phase; Portable; SI; HPLC

This Small Business Innovation Research (SBIR) Phase I project proposes the development of a portable and fully automated chromatographic based analyzer. This analyzer will integrate several proven technologies to produce an automated instrument that is compact, robust and easily implemented for on-line, at-site, or field-ready use, especially where complex HPLC (High Performance Liquid Chromatography) analyses are needed. Based on Sequential Injection (SI) protocol and HPLC instrumentation, this instrument will be full automated and provide an integrated approach with respect to sample collection, pretreatment, chemical modification, separation and detection of target analytes. This chemical analyzer will exploit several novel technologies including sequential injection, portable high-pressure syringe pumps and sol-gel HPLC columns in its development of this hybrid analyzer referred to as Sequential Injection for High performance Liquid Chromatography (SI-HPLC). Although HPLC is a fundamental fixture in many laboratories; it remains largely a bench-top instrument due to its overall large size, high power consumption and need for manual sample retreatment/preparation prior to analysis. By integrating several evolving technologies, HPLC analysis can be fully automated and conducted at much lower pressures, which will also make this analyzer very compact and truly portable as well as energy efficient. The proposed SI-HPLC instrument will find applications at on-line process control, at-site environmental monitoring or as a multipurpose field-ready analyzer for medical, law-enforcement or military use. The SI-HPLC instrument will be a low cost, portable system that is highly adaptable to different applications since it will rely on an open architecture made possible by software programmability. Sequential Injection technologies make this analyzer ideally suited for use by untrained personnel or for remote autonomous analysis since sample handling and preparation can be completely automated. Examples for SI-HPLC use will be for online process control (e.g. pharmaceuticals) to provide real-time feedback for Quality Control or optimal product yield; at-site monitoring of pesticide or leachate contamination of water sources; or as a field-ready analyzer for mobile hospital units. The SI-HPLC instrument will have broad application since it will employee widely accepted/desired HPLC methodologies into a completely portable and cost-effective field analyzer.

这个小型企业创新研究(SBIR)第一阶段项目建议开发一种便携式和全自动的基于色谱的分析仪。该分析仪将集成几种成熟的技术，以生产一种紧凑、坚固、易于实施的自动化仪器，供在线、现场或现场使用，特别是在需要复杂的高效液相色谱(High Performance Liqumatography)分析的情况下。该仪器将基于顺序注射(SI)协议和高效液相色谱仪器，实现全自动化，为样品采集、前处理、化学修饰、目标分析物的分离和检测提供一体化的方法。该化学分析仪将利用几项新技术，包括顺序注射、便携式高压注射泵和溶胶-凝胶高效液相色谱柱，以开发这种被称为顺序注射高效液相色谱(SI-HPLC)的混合分析仪。虽然高效液相色谱是许多实验室的基本固定装置，但由于其整体尺寸大、功耗高且需要在分析前进行人工样品再处理/准备，因此在很大程度上仍是一种台式仪器。通过集成几种不断发展的技术，高效液相分析可以完全自动化，并在低得多的压力下进行，这也将使该分析仪非常紧凑，真正的便携以及能源效率。建议的SI-HPLC仪将在在线过程控制、现场环境监测或作为医疗、执法或军事用途的多用途现场就绪分析仪方面得到应用。SI-HPLC仪器将是一种低成本、便携的系统，可高度适应不同的应用，因为它将依赖于由软件可编程性实现的开放式架构。顺序进样技术使该分析仪非常适合未经培训的人员使用或远程自主分析，因为样品处理和制备可以完全自动化。SI-HPLC的应用实例包括在线过程控制(例如药品)，为质量控制或最佳产品产量提供实时反馈；现场监测水源的农药或渗滤液污染；或作为流动医院单位的现场准备分析器。SI-HPLC仪具有广泛的应用前景，因为它将把被广泛接受/期望的高效液相色谱方法应用到完全便携且经济实惠的现场分析仪中。