LSC: Bloomington Drosophila Stock Center at Indiana University

摘要这是印第安纳州大学布卢明顿果蝇储备中心（BDSC）的五年更新奖。生物系的Kathleen马修斯博士是PI，CoPI包括Kevin Cook博士和托马斯考夫曼博士。BDSC是一个国际公认的股票中心，收集，维护和分发果蝇的遗传股票。它支持一个庞大而活跃的研究社区，通过使用在这种流行的模式生物中开发的复杂遗传工具来调查基本的生物过程。目前的用户群包括56个国家的2，400多个研究小组和35个教学单位。61%的中心使用来自美国科学家，98%的使用来自学术研究人员。BDSC提供了一个全面的菌株选择，支持果蝇研究的全方位。该系列包括超过20，000种不同的遗传菌株，包含超过95，000种定义的遗传元件，包括突变，染色体畸变和转座子插入以及基因错误表达，位点特异性重组和转基因工具。BDSC将继续维护一个网站，提供有关库存、其实验用途、订购和账户信息以及监管问题的信息。有关布卢明顿种群遗传成分的信息完全集成到果蝇工作者的主要遗传和基因组学数据库FlyBase中。来自布卢明顿的果蝇品系一直是基因调控、细胞生物学、发育生物学、神经生物学、行为生物学、种群生物学、生态学和进化实验的关键组成部分，并将继续在许多生物奋进领域产生广泛的影响。中心将通过数据库和网站http://flystocks.bio.indiana.edu提供BDSC信息，以确保库存得到有效利用。

Abstract This is a five-year renewal award to the Bloomington Drosophila Stock Center (BDSC) at Indiana University. Dr. Kathleen Matthews in the Department of Biology is the PI and CoPIs include Drs. Kevin Cook and Thomas Kaufman. The BDSC is an internationally-recognized stock center that collects, maintains and distributes genetic stocks of the fly Drosophila melanogaster. It supports a large and active research community investigating fundamental biological processes through the use of the sophisticated genetic tools developed in this popular model organism. Its current user base includes more than 2,400 research groups and 35 teaching units in 56 countries. 61% of Center use comes from U.S. scientists and 98% of use comes from academic researchers. BDSC provides a comprehensive selection of strains supporting the full spectrum of Drosophila research. The collection consists of over 20,000 different genetic strains containing over 95,000 defined genetic elements including mutations, chromosomal aberrations and transposon insertions as well as tools for gene misexpression, site-specific recombination and transgenesis. BDSC will continue to maintain a website which will provide information concerning stocks, their experimental uses, ordering and account information, and regulatory issues. Information about genetic components of Bloomington stocks is fully integrated into FlyBase, the primary genetic and genomics database for Drosophila workers. Drosophila strains from Bloomington have been key components in experiments in gene regulation, cell biology, developmental biology, neurobiology, behavioral biology, population biology, ecology and evolution and will continue to have a broad impact in many fields of biological endeavor. The Center will assure that the stocks are used effectively by making BDSC information available through databases and websites found at http://flystocks.bio.indiana.edu