Purchase of a Stopped Flow Optical Spectrometer with Freeze-Quench Capability

有了化学研究仪器和设施（CRIF）计划的这一奖项，Bermigie-Mellon大学化学系将获得具有冷冻淬火能力的停流光谱仪。该设备将加强以下领域的研究：a）研究自旋状态对一系列铁络合物的电子转移速率的影响; B）基于有机金属铁络合物的氧化催化剂的合成和表征; c）研究蛋白质羟胺氧化还原酶中的血红素基团; d）合成肽核酸; e）从聚集在DNA上的染料分子进行的自组装纳米结构研究;以及f）蛋白质结构和功能研究。 光谱学最常用于表征系统的平衡性质。 这种方法也可以通过比较反应前后的光谱来研究分子的化学反应性。 然而，为了充分理解给定化合物的反应性范围和机制，重要的是要在真实的时间内对其进行研究。 停流仪器将允许几名教师和他们的学生研究分子识别过程和化学反应的动力学，用于各种将化学与生物，材料和环境科学相结合的项目。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Carnegie-Mellon University will acquire a stopped flow optical spectrometer with freeze-quench capability. This equipment will enhance research in the following areas: a) studies on the effect of spin states on the electron transfer rates for a series of iron complexes; b) synthesis and characterization of oxidation catalysts based on organometallic iron complexes; c) studies of hemes groups in the protein hydroxylamine oxidoreductase; d) synthesis of peptide nucleic acids; e) studies of self-assembled nanostructures from dye molecules aggregated on DNA; and f) protein structure and function studies. Spectroscopy is most commonly used to characterize the equilibrium properties of a system. This method can also be used to study the chemical reactivity of molecules by comparing spectra before and after reaction. However, to fully understand the scope and mechanism of reactivity for a given compound, it is important to study it in real time. The stopped-flow instrumentation will allow several faculty members and their students to study the kinetics of molecular recognition processes and chemical reactions for a variety of projects that interface chemistry with the biological, materials and environmental sciences.