Purchase of a Stopped Flow Optical Spectrometer with Freeze-Quench Capability

卡内基梅隆大学化学系将获得化学研究仪器和设施(CRIF)计划颁发的这一奖项，从而获得一台具有冷冻淬火能力的停流光学光谱仪。该设备将加强以下领域的研究：a)自旋态对一系列铁络合物电子转移速率的影响的研究；b)基于有机金属铁络合物的氧化催化剂的合成和表征；c)蛋白质羟胺氧化还原酶中血红素基团的研究；d)肽核酸的合成；e)染料分子聚集在DNA上的自组装纳米结构的研究；f)蛋白质结构和功能的研究。光谱学最常用来描述体系的平衡性质。这种方法还可以通过比较反应前后的光谱来研究分子的化学反应活性。然而，为了充分了解给定化合物的反应范围和反应机理，实时研究它是很重要的。停流仪器将允许几名教职员工和他们的学生为各种将化学与生物、材料和环境科学相结合的项目研究分子识别过程和化学反应的动力学。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Carnegie-Mellon University will acquire a stopped flow optical spectrometer with freeze-quench capability. This equipment will enhance research in the following areas: a) studies on the effect of spin states on the electron transfer rates for a series of iron complexes; b) synthesis and characterization of oxidation catalysts based on organometallic iron complexes; c) studies of hemes groups in the protein hydroxylamine oxidoreductase; d) synthesis of peptide nucleic acids; e) studies of self-assembled nanostructures from dye molecules aggregated on DNA; and f) protein structure and function studies. Spectroscopy is most commonly used to characterize the equilibrium properties of a system. This method can also be used to study the chemical reactivity of molecules by comparing spectra before and after reaction. However, to fully understand the scope and mechanism of reactivity for a given compound, it is important to study it in real time. The stopped-flow instrumentation will allow several faculty members and their students to study the kinetics of molecular recognition processes and chemical reactions for a variety of projects that interface chemistry with the biological, materials and environmental sciences.