Purchase of a Stopped Flow Optical Spectrometer with Freeze-Quench Capability

根据化学研究仪器和设施（CRIF）计划的这份合同，卡内基-梅隆大学化学系将获得一台具有冷冻猝灭能力的停止流动光学光谱仪。该设备将加强以下领域的研究：a)研究自旋态对一系列铁配合物电子转移速率的影响；B)有机金属铁配合物氧化催化剂的合成与表征；C)蛋白质羟胺氧化还原酶中血红素基团的研究；D)多肽核酸的合成；e)染料分子聚集在DNA上的自组装纳米结构的研究；f)蛋白质结构和功能研究。光谱学最常用来描述系统的平衡特性。该方法还可以通过比较反应前后的光谱来研究分子的化学反应性。然而，为了充分了解给定化合物的反应范围和反应机制，对其进行实时研究是很重要的。该止流仪器将允许一些教师和他们的学生研究分子识别过程的动力学和化学反应的各种项目，将化学与生物，材料和环境科学相结合。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Carnegie-Mellon University will acquire a stopped flow optical spectrometer with freeze-quench capability. This equipment will enhance research in the following areas: a) studies on the effect of spin states on the electron transfer rates for a series of iron complexes; b) synthesis and characterization of oxidation catalysts based on organometallic iron complexes; c) studies of hemes groups in the protein hydroxylamine oxidoreductase; d) synthesis of peptide nucleic acids; e) studies of self-assembled nanostructures from dye molecules aggregated on DNA; and f) protein structure and function studies. Spectroscopy is most commonly used to characterize the equilibrium properties of a system. This method can also be used to study the chemical reactivity of molecules by comparing spectra before and after reaction. However, to fully understand the scope and mechanism of reactivity for a given compound, it is important to study it in real time. The stopped-flow instrumentation will allow several faculty members and their students to study the kinetics of molecular recognition processes and chemical reactions for a variety of projects that interface chemistry with the biological, materials and environmental sciences.