Composite Colloidal Particles Produced by Carbon Dioxide Assisted Microencapsulation

二氧化碳辅助微胶囊化制备复合胶体颗粒

• 批准号: 0343774
• 负责人: Matthew Yates
• 金额: $ 25万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2007-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0343774&HistoricalAwards=false
• 关键词: Composite; Colloidal; Particles; Produced; Carbon

Microencapsulation is the process of embedding an additive in a colloidal particle.This technology is widely used to provide extended release of entrapped compounds suchas drugs or fragrances. However, microencapsulation may be used to produce compositeparticles with controlled optical, chemical, or physical properties for a wealth ofapplications. Current microencapsulation technology typically requires organic solventsthat are difficult to remove from the polymer. Residual solvent is especially undesirable forfood and drug applications where the maximum allowable concentration is very low. Wepropose to study the transport of additives into colloidal polymer particles dispersed in anemulsion of liquid or supercritical carbon dioxide and water in an effort to reduce oreliminate the need for organic solvents. At elevated pressures, carbon dioxide swells andplasticizes the polymer particles, facilitating mass transport. Surfactants are used tostabilize the emulsion of CO2 and water. The surfactants also adsorb on the surface of theparticles to enhance colloidal stability. After depressurization, the polymer particles returnto their original size and shape, entrapping the additive. The adsorbed surfactant remainson the surface and thus offers a route to controlling the surface chemistry of the particles.Biodegradable and biocompatible polymer colloids will be impregnated with drugs,chromophores, and luminescent nanoparticles with the aid of CO2, water, and non-toxicsurfactants. In addition, we propose to couple CO2 processing with traditionalmicroencapsulation techniques to lower residual solvent content and sterilize polymerparticles. The proposed research will provide a flexible, biologically and environmentallyfriendly route to the production of composite particles used as devices for drug delivery,tracers and indicators for drug discovery and genomics, and other composite colloidalparticles useful for catalysis, coatings, and optical materials. To broaden the impact of theproposed research, a computer based instructional module on microencapsulationtechnology will be developed and incorporated into the course 'Interfacial Engineering' atthe University of Rochester with the assistance of a commercial educational softwarevendor. The software vendor has expressed interest in incorporating the module into theirexisting software for broader distribution. Undergraduate and graduate students fromdiverse backgrounds will be recruited to work on the project through existing programs atthe University of Rochester.

微胶囊化是将添加剂包埋在胶体颗粒中的过程。这项技术被广泛用于提供包埋化合物如药物或香料的缓释。然而，微胶囊化可用于生产具有受控光学、化学或物理性质的复合颗粒，以用于大量应用。目前的微胶囊技术通常需要有机溶剂，难以从聚合物中除去。残留溶剂对于食品和药品应用是特别不希望的，其中最大允许浓度非常低。为了减少或消除对有机溶剂的需求，我们建议研究添加剂向分散在液体或超临界二氧化碳和水的乳液中的胶体聚合物颗粒中的传输。在高压下，二氧化碳膨胀并塑化聚合物颗粒，促进质量传递。表面活性剂用于稳定CO2和水的乳液。表面活性剂还吸附在颗粒表面以增强胶体稳定性。减压后，聚合物颗粒恢复到原来的大小和形状，包埋添加剂。吸附的表面活性剂吸附在表面上，从而提供了一条控制颗粒表面化学性质的途径。在CO2、水和无毒表面活性剂的帮助下，可生物降解和生物相容的聚合物胶体将被药物、发色团和发光纳米颗粒浸渍。此外，我们建议将CO2处理与传统的微胶囊化技术相结合，以降低残留溶剂含量并对聚合物颗粒进行灭菌。拟议的研究将提供一个灵活的，生物和环境友好的路线，用于生产复合颗粒作为药物输送，示踪剂和指示剂的药物发现和基因组学，以及其他复合胶体颗粒用于催化，涂层和光学材料。为了扩大拟议的研究的影响，一个基于计算机的教学模块，对microprocessoration技术将开发和纳入课程“界面工程”在罗切斯特大学的商业教育软件供应商的援助。该软件供应商表示有兴趣将该模块纳入其现有的软件中，以便更广泛地分发。将通过罗切斯特大学现有的项目招募来自不同背景的本科生和研究生参与该项目。