ACT/SGER: Extremely Sensitive Fluorescent Detection of Organophosphate Nerve Agents

ACT/SGER：有机磷神经毒剂的极其灵敏的荧光检测

• 批准号: 0346374
• 负责人: Neal Zondlo
• 金额: $ 10万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0346374&HistoricalAwards=false
• 关键词: ACT; SGER; Extremely; Sensitive; Fluorescent

Professor Neal Zondlo of the University of Delaware is developing a fluorescence-based device for the detection of trace quantities of organophosphate nerve agents. These agents, if present, will react with the acetylcholinesterase enzyme and detection will be made either directly or via fluorescent detection of cholinesterase activity. Since it should be possible to detect sublethal amounts, the device should be helpful in preventing terrorist attacks before they occur. Both graduate and undergraduate students will participate in the project.This award is supported jointly by the NSF and the Intelligence Community. The Approaches to Combat Terrorism Program in the Directorate for Mathematics and Physical Sciences supports new concepts in basic research and workforce development with the potential to contribute to national security.

特拉华州大学的Neal Zondlo教授正在开发一种基于荧光的设备，用于检测痕量的有机磷酸盐神经毒剂。 如果存在，这些试剂将与乙酰胆碱酯酶反应，并将直接或通过荧光检测胆碱酯酶活性进行检测。 由于应该可以检测亚致命量，该装置应该有助于在恐怖袭击发生之前预防恐怖袭击。 研究生和本科生都将参与这个项目。这个奖项是由美国国家科学基金会和情报界共同支持的。 数学和物理科学局的打击恐怖主义办法方案支持基础研究和劳动力发展方面的新概念，这些概念有可能促进国家安全。