CAREER: Understanding Cellular and Molecular Mechanics with Nano-/Micro-technology

职业：利用纳米/微米技术了解细胞和分子力学

• 批准号: 0347191
• 负责人: Philip LeDuc
• 金额: $ 39.61万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0347191&HistoricalAwards=false
• 关键词: CAREER; Understanding; Cellular; Molecular; Mechanics

National Science FoundationCAREER: Understanding Cellular and Molecular Mechanics with Nano-/Micro-technologyPhilip LeDucAbstractThe traditional boundaries between engineering and the life sciences are rapidly disintegrating as interdisciplinary research teams develop new engineering tools for further exploring fundamental questions in medicine and biology. This fusion promises to uncover complex cell interactions by linking molecular function to cellular behavior in the area of mechanics. Recent advances in nanotechnology are enabling experiments on individual cells and molecules to test the hypothesis that intracellular structural deformation in mammalian cells is locally controlled by mechanical perturbations through the response of sub-cellular domains. The broader impact of these studies is hoped to benefit society through ultimately leading to the development of treatments for pathological conditions in which cellular mechanics and structure are believed to play an important role: heart disease, osteoporosis, and cancer. The technical merit of this proposal will focus on determining the link between molecular interactions and cell structure by identifying unique structural function and behavior.

国家科学基金会职业生涯：理解细胞和分子力学与纳米/微米technologyPhilip LeDucAbstract工程和生命科学之间的传统界限正在迅速瓦解作为跨学科的研究团队开发新的工程工具，进一步探索医学和生物学的基本问题。这种融合有望通过将分子功能与力学领域的细胞行为联系起来来揭示复杂的细胞相互作用。 纳米技术的最新进展使对单个细胞和分子的实验能够检验哺乳动物细胞中的细胞内结构变形是通过亚细胞结构域的响应由机械扰动局部控制的假设。这些研究的更广泛的影响，希望通过最终导致治疗的病理条件，其中细胞力学和结构被认为发挥了重要作用的发展造福社会：心脏病，骨质疏松症和癌症。该提案的技术优点将集中在通过识别独特的结构功能和行为来确定分子相互作用与细胞结构之间的联系。