EAGER: Transitioning to Millifluidics: 2D Microfluidic Controls for 3D Profile Manipulation

EAGER：过渡到微流体：用于 3D 轮廓操纵的 2D 微流体控制

• 批准号: 1013748
• 负责人: Philip LeDuc
• 金额: $ 11.96万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1013748&HistoricalAwards=false
• 关键词: EAGER; Transitioning; Millifluidics; 2D; Microfluidic

The research objectives and approaches of this project are focused on examining fluid flow at small scales. As the idea of scaling up microfluidics systems to millifluidic counterparts gains greater scientific attention, as opposed to the significant body of work scaling down to nanofluidics, this work focuses on a simple two-dimensional approach for micro- and milli-fluidics to create three-dimensional chemical profiles using single-layer microfluidic modules. Not only can a three-dimensional pattern be created, but with simple changes in the planar configuration, the three-dimensional chemical pattern can be controlled including through the speed of the fluid and the height of the channels. Future larger-scale fluidic experiments may have limitations due to resulting non-obvious three-dimensional profiles, which are dependent on basic parameter choices.The society benefits are that findings from this project will be transformative and result in high-risk/high-payoff by expanding possibilities in areas such as embryonic development and optofluidics. This work will also have an impact in fields from small scale chemical mixing to developing future therapies through understanding disease related biological systems as well as to researchers in engineering, microfluidics, millifluidics, cellular stimulation, mixing layers, optical imaging, and chemical fabrication approaches. The education effort is to build an education and training pipeline for preparing future leaders in engineering and science. This will be accomplished through work with kindergarten to 12th grade students as well as graduate students. These efforts will include working with Pittsburgh's Lincoln Technology Academy, which is in one of the most academically challenged neighborhoods in Pennsylvania.

该项目的研究目标和方法侧重于检查小尺度的流体流动。随着将微流体系统扩大到毫流体系统的想法获得了更多的科学关注，而不是大量的工作缩小到纳米流体，这项工作重点关注微流体和毫流体的简单二维方法，以使用单层微流体模块创建三维化学剖面。不仅可以创建三维图案，而且通过平面配置的简单改变，可以通过流体的速度和通道的高度来控制三维化学图案。未来更大规模的流体实验可能会受到限制，因为产生的三维轮廓不明显，这取决于基本参数的选择。社会效益是，该项目的发现将具有变革性，并通过扩大胚胎发育和光流控等领域的可能性，带来高风险/高回报。这项工作还将对小规模化学混合、通过了解疾病相关生物系统来开发未来疗法以及工程、微流体、微流体、细胞刺激、混合层、光学成像和化学制造方法的研究人员产生影响。教育工作旨在建立教育和培训渠道，为未来的工程和科学领导者做好准备。这将通过与幼儿园至 12 年级学生以及研究生的合作来完成。这些努力将包括与匹兹堡林肯技术学院合作，该学院位于宾夕法尼亚州学术上最困难的社区之一。