CAREER: Organic Nanoparticles

职业：有机纳米粒子

• 批准号: 0348955
• 负责人: Edward Van Keuren
• 金额: $ 51.24万
• 依托单位: Georgetown University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-15 至 2010-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0348955&HistoricalAwards=false
• 关键词: CAREER; Organic; Nanoparticles

The focus of this research is the study of organic nanoparticles prepared using an arrested precipitation method called "solvent shifting." This plan will involve study of fundamental aspects of the nucleation and growth of the nanoparticles, especially the role of diffusion in supersaturated solutions and the connection to solution crystallization. Mechanisms of the particle growth will be determined in order to develop methods of stabilization and separation from the solvent. Organic nanoparticles will be used in a number of innovative applications such as polymer nanoparticles with narrow size distributions, nanocomposite light emitting diodes, and nanoscale electronic components. The plan is integrated with undergraduate training in optics and materials, both through research participation and the development of an online optics reference book. This reference book will have several innovative features, including distributed authorship and the use of active learning by undergraduates in the creation and revision of the material and the delivery of multiple levels of content. A significant undergraduate participation in the organic nanoparticle research is also planned, along with further development of a novel graduate program in industrial physics. %%%The main goal of this research project is to gain a better understanding of the underlying processes of aggregation and self-assembly of organic molecules. A number of novel optical characterization methods will be used to do this, including fluorescence correlation spectroscopy, which looks at optical emission from small groups of, or even single molecules, and diffusion measurements in microfabricated mixing cells. There are many potential applications for these types of organic nanoparticles, ranging from novel optical materials to biocompatible drug formulations. Several applications will be explored: polymer dispersions with well-controlled sizes and shapes, composites of nanoparticles for optical displays, and nano-electronics using chains of organic nanoparticles. The plan is integrated with undergraduate training in optics and materials, both through research participation and the development of a novel online optics reference book. This reference book will have several innovative features, including distributed authorship and the use of active learning by undergraduates in the creation and revision of the material and the delivery of multiple levels of content.***

本研究的重点是利用一种被称为“溶剂转移”的抑制沉淀法制备有机纳米粒子。“该计划将涉及纳米粒子成核和生长的基本方面的研究，特别是扩散在过饱和溶液中的作用以及与溶液结晶的联系。将确定颗粒生长的机制，以开发稳定和从溶剂中分离的方法。有机纳米颗粒将用于许多创新应用，例如窄尺寸分布的聚合物纳米颗粒、纳米复合发光二极管和纳米级电子元件。该计划与光学和材料的本科生培训相结合，通过参与研究和开发在线光学参考书。这本参考书将有几个创新的特点，包括分布式作者和使用主动学习的本科生在创建和修改的材料和交付多层次的内容。一个显着的本科生参与有机纳米粒子的研究也计划，沿着进一步发展的一个新的研究生课程在工业物理。本研究项目的主要目标是更好地了解有机分子聚集和自组装的基本过程。一些新的光学表征方法将被用来做到这一点，包括荧光相关光谱，它着眼于从小群体，甚至单个分子的光发射，和扩散测量在微制造的混合细胞。这些类型的有机纳米颗粒有许多潜在的应用，从新型光学材料到生物相容性药物制剂。几个应用将被探索：聚合物分散体与良好控制的大小和形状，复合材料的纳米粒子的光学显示器，和纳米电子使用链的有机纳米粒子。该计划与光学和材料的本科生培训相结合，通过参与研究和开发一种新颖的在线光学参考书。这本参考书将有几个创新的特点，包括分布式作者和使用主动学习的本科生在创建和修改的材料和交付多层次的内容。