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Titanium catalyzed multi-component coupling strategies based on hydroamination of alkynes

基于炔烃加氢胺化的钛催化多组分偶联策略

基本信息

批准号：
0350762
负责人：
Aaron Odom
金额：
$ 37.8万
依托单位：
Michigan State University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2004
资助国家：
美国
起止时间：
2004-03-01 至 2007-02-28
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0350762&HistoricalAwards=false
关键词：
Titanium catalyzed multi component coupling

项目摘要

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports Professor Aaron Odom of Michigan State University for his research exploring the development and elaboration of pyrrolyl-based ligands in early transition metal-based catalysis. Prof. Odom will investigate the formation of C-N bond forming reactions, especially in the synthesis of heterocycles, through the investigation of new titanium-based catalysts. The development of hydroamination catalysts will be furthered by the elucidation of the structural features and electronic structures of key intermediates to understand the factors governing metal-ligand multiple band reactivity. This research will advance the chemistry needed for the organic transformations of heterocyclic frameworks such as pyrroles, indoles and quinolines that are important in the development of the majority of fine chemicals including pharmaceuticals.The development of new reaction chemistry and catalysts for C-N bond formation is a critical step to improve the methodology for the synthesis of a variety of compounds such as pyrroles, indoles and quinolines, many of which are important specialty and pharmaceutical compounds This research will allow the generation of organic compounds with relatively high molecular complexity from simple starting materials. Graduate students, undergraduate students and postdoctoral associates will receive excellent training in synthetic methodology, and the electronic structure studies of metal complexes in a forefront inorganic chemistry program.

这个奖项在无机，生物无机和有机化学计划支持教授亚伦奥多姆密歇根州立大学为他的研究探索的发展和制定吡咯基配体在早期过渡金属为基础的催化。 Odom教授将通过研究新的钛基催化剂，研究C-N键形成反应的形成，特别是在杂环的合成中。氢胺化催化剂的发展将进一步阐明的结构特征和关键中间体的电子结构，以了解控制金属配体的多带反应性的因素。这项研究将推进杂环框架如吡咯、吲哚和喹啉的有机转化所需的化学，这些杂环框架在包括药物在内的大多数精细化学品的开发中是重要的。新的反应化学和C-N键形成催化剂的开发是改进各种化合物如吡咯、吲哚和喹啉的合成方法的关键步骤，其中许多是重要的专业和药物化合物这项研究将允许从简单的起始材料生成具有相对高分子复杂性的有机化合物。研究生，本科生和博士后助理将接受合成方法学的优秀培训，以及前沿无机化学计划中金属络合物的电子结构研究。