Development of Titanium Catalysts and Multicomponent Coupling Strategies Applicable to Heterocyclic Synthesis

密歇根州立大学的Aaron L. Odom教授在化学系化学催化（CAT）项目的支持下，探索钛配合物的性质和反应性，重点是催化生产杂环化合物的新反应。主要的焦点将是烷烃和烯烃的氢胺化，这是生成C？N债券。在单一合成步骤中产生复杂有机化合物的多组分偶联反应以及用于多组分偶联化学的表面系固催化剂体系的路线将被研究。钛基化学的优点包括钛？天然丰度高，毒性低。新型原子经济反应化学及其催化剂的发展氮键的形成对于各种氮基杂环的高效、绿色合成至关重要。这些氮杂环在影响我们日常生活的许多领域都有应用。例如，市场上大约80%的药品含有氮，许多是以氮杂环的形式存在的。这项研究预计将对制药和精细化工行业产生直接影响。参与本研究的研究生、本科生和博士后将接受化学催化和合成化学方面的优秀培训。

Professor Aaron L. Odom of Michigan State University is supported by the Chemical Catalysis (CAT) Program in the Division of Chemistry to explore the properties and reactivity of titanium complexes with a focus on new reactions for the catalytic production of heterocyclic compounds. The main focus will be on the hydroamination of alkynes and alkenes, which are atom-economical synthetic methodologies for the generation of C?N bonds. Multi-component coupling reactions that yield complex organic compounds in a single synthetic step as well as routes to surface-tethered catalyst systems for multicomponent coupling chemistry will be investigated. The advantages of titanium-based chemistry include titanium?s high natural abundance and lack of toxicity. The development of new atom-economical reaction chemistry and catalysts for C?N bond formation is critical for the efficient, green synthesis of a variety of nitrogen-based heterocycles. These nitrogen heterocycles have applications in many areas that impact our daily lives. For example, around 80% of the pharmaceuticals on the market contain nitrogen, many in the form of nitrogen heterocycles. This research is expected to have an immediate impact on the pharmaceutical and fine chemicals industry. Graduate and undergraduate students and postdoctoral associates involved in this research will receive excellent training in chemical catalysis and synthetic chemistry.