Epidemiology of motoneuron diseases in Swabia

斯瓦比亚运动神经元疾病的流行病学

• 批准号: 165849180
• 负责人: Professor Dr. Albert Christian Ludolph
• 金额: --
• 依托单位: Universitätsklinik für Neurologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/165849180?language=en
• 关键词: Epidemiology; motoneuron; diseases; Swabia

During the previous funding period we were able to successfully implement the first clinical epidemiological register for amyotrophic lateral sclerosis (ALS) in Germany. In order to allow international comparisons and future collaborations, the instruments were coordinated with those of the European ALS MND group (EURALS), beyond the established methodology was used to a register in China (Beijing: 10 million people covered) and Mongolia (Ulanbaatar:1.5 million persons covered) establish.The age-standardized incidence of ALS in Swabia is 2.5 (95% CI 2.3 to 2.7) per 100,000 people, and is consistent with estimates from other European registries. The completeness has been tested with the capture-recapture method and is estimated to be 81%. From 1.10.2010, ALS patients were recruited in a case-control study and frequency matched to control subjects in order to explore on possible risk factors. From most patients and control subjects bio material has been collected. The objectives of the first phase were realized with the establishment of effective structures and quality assured processes for implementing register-based studies and confirmed by first publications.Recent publications show a correlation between the frontotemporal dementia (FTD) and ALS. To account for this phenotype in future evaluations, FTD cases will additionally be recorded in the register and a modified method will be applied.We will conduct a comparative analysis of the ALS Registry Swabia with other registries of European EURALS Group and the cooperation partners in China and Mongolia. Once, expected end of 2013, as required by the power calculations case numbers are achieved statistical evaluation of the case-control study will be conducted with the involvement of biological material. In addition, we will continue to pursue the study of spatial patterns of the ALS disease risk.

在之前的资助期间，我们成功地在德国实施了第一个肌萎缩侧索硬化症(ALS)临床流行病学登记。为了进行国际比较和未来的合作，这些工具与欧洲ALS MND小组(EURALS)的工具进行了协调，超出了既定的方法用于中国(北京：1000万人覆盖)和蒙古(乌兰巴托：150万人覆盖)机构的登记。斯瓦比亚ALS的年龄标准化发病率为每10万人2.5(95%可信区间2.3至2.7)，与其他欧洲登记机构的估计一致。用捕获-再捕获方法对其完备性进行了测试，估计完备率为81%。从2010年10月1日起，ALS患者被纳入病例对照研究，频率与对照组匹配，以探索可能的危险因素。从大多数患者和对照受试者那里收集了生物材料。第一阶段的目标是通过建立有效的结构和质量保证程序来实施基于登记的研究，并得到第一批出版物的证实。最近的出版物表明额颞痴呆(FTD)与ALS之间存在相关性。为了在未来的评估中考虑到这种表型，FTD病例将被额外记录在登记册中，并将采用改进的方法。我们将对ALS注册表Swabia与欧洲EURALS集团的其他注册表以及中国和蒙古的合作伙伴进行比较分析。一旦，预计2013年底，按照权力计算的要求，病例数量得到实现，将对涉及生物材料的病例对照研究进行统计评价。此外，我们将继续研究肌萎缩侧索硬化症疾病风险的空间模式。

项目成果

A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts

• DOI: 10.1016/j.neurobiolaging.2012.10.009
• 发表时间: 2013-06-01
• 期刊: NEUROBIOLOGY OF AGING
• 影响因子: 4.2
• 作者: Ingre, Caroline;Landers, John E.;Weishaupt, Jochen H.
• 通讯作者: Weishaupt, Jochen H.

Phenotypic differences of amyotrophic lateral sclerosis (ALS) in China and Germany

• DOI: 10.1007/s00415-018-8735-9
• 发表时间: 2018-04-01
• 期刊: JOURNAL OF NEUROLOGY
• 影响因子: 6
• 作者: Rosenbohm, Angela;Liu, Mingsheng;Ludolph, Albert C.
• 通讯作者: Ludolph, Albert C.

Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis

• DOI: 10.1136/jnnp-2017-315795
• 发表时间: 2017-12-01
• 期刊: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
• 影响因子: 11
• 作者: Gorges, Martin;Vercruysse, Pauline;Dupuis, Luc
• 通讯作者: Dupuis, Luc

Incidence and Geographical Variation of Amyotrophic Lateral Sclerosis (ALS) in Southern Germany – Completeness of the ALS Registry Swabia

德国南部肌萎缩侧索硬化症 (ALS) 的发病率和地理变化 â 施瓦本 ALS 登记的完整性

• DOI: 10.1371/journal.pone.0093932
• 发表时间: 2014
• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: Uenal H;Rosenbohm A;Kufeldt J;Weydt P;Goder K;Ludolph A;Rothenbacher D;Nagel G;ALS registry Study Group
• 通讯作者: ALS registry Study Group

Life course body mass index and risk and prognosis of amyotrophic lateral sclerosis: results from the ALS registry Swabia

• DOI: 10.1007/s10654-017-0318-z
• 发表时间: 2017-10-01
• 期刊: EUROPEAN JOURNAL OF EPIDEMIOLOGY
• 影响因子: 13.6
• 作者: Peter, Raphael Simon;Rosenbohm, Angela;Ludolph, Albert Christian
• 通讯作者: Ludolph, Albert Christian