CRC: Exploiting Self-Assembly in Biological and Synthetic Macromolecules to Create Novel Hybrid Materials

CRC：利用生物和合成大分子的自组装来创造新型混合材料

• 批准号: 0404575
• 负责人: Thomas Russell
• 金额: --
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0404575&HistoricalAwards=false
• 关键词: CRC; Exploiting; Self; Assembly; Biological

Anna Balazs, Gilbert Walker, Thomas Russell, and Todd Emrick are supported with a collaborative award to study self-assembly processes. Additional partners in this collaboration include Craig Hawker (IBM Almaden), Linda Molnar (NASA) and Jonathan Trent (NASA). Their goal is to create novel materials by exploiting synergistic interactions that arise when two distinct self-assembling processes occur silmultaneously in one system. One component is chaperonin proteins that self-assemble into fibers, bundles or sheets, the other is synthetic block copolymers that form lamellar, cylindrical, spherical and more complicated phases. By linking or embedding one phase in another, one self-organization process can influence the other and lead to novel new assemblies. This study integrates theory and experiment to probe cooperative behavior and understand fundamental self-assembly processes. Understanding how synthetic molecules interact with biological molecules is essential to biomaterials and biosensors. Potential applications of this research include antimicrobial coatings, responsive materials, drug delivery and biomolecular electronics. This project is funded through the Collaborative Research in Chemistry Program (CRC) and provides outstanding opportunities for undergraduates, graduate students, and postdoctoral researchers to acquire knowledge and skills in very broad areas of research, including materials synthesis, theory, polymer engineering, physical chemistry and nanoscience.

安娜巴拉兹、吉尔伯特步行者、托马斯拉塞尔和托德埃姆里克获得了研究自组装过程的合作奖。此次合作的其他合作伙伴包括克雷格霍克（IBM Almaden）、琳达莫尔纳（NASA）和乔纳森特伦特（NASA）。他们的目标是通过利用当两个不同的自组装过程在一个系统中同时发生时产生的协同相互作用来创造新材料。一种成分是伴侣蛋白，其自组装成纤维、束或片，另一种成分是合成的嵌段共聚物，其形成层状、圆柱形、球形和更复杂的相。通过将一个阶段连接或嵌入另一个阶段，一个自组织过程可以影响另一个阶段，并导致新的组装。本研究结合理论与实验，探讨合作行为与了解基本的自我组装过程。了解合成分子如何与生物分子相互作用对于生物材料和生物传感器至关重要。这项研究的潜在应用包括抗菌涂层，响应材料，药物输送和生物分子电子学。该项目通过化学合作研究计划（CRC）资助，并为本科生，研究生和博士后研究人员提供出色的机会，以获得非常广泛的研究领域的知识和技能，包括材料合成，理论，聚合物工程，物理化学和纳米科学。