Targeting genes elevated in the athlete's heart to improve function of the failing heart

针对运动员心脏中升高的基因以改善衰竭心脏的功能

• 批准号: FT0991657
• 负责人: Dr Julie McMullen
• 金额: $ 48.96万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT0991657
• 关键词: Targeting; genes; elevated; athlete; heart

Cardiovascular disease affects about 3.7 million Australians and heart failure ranks as one of the major killers, representing a huge burden on our health care system and economy. This situation is likely to get worse with an increasing ageing population. Current therapeutics for heart failure patients largely delay disease progression but generally fail in significantly improving heart function and quality of life. The proposal has focused on targeting the protective effects of 'good' heart growth by identifying genes elevated in the heart in response to exercise. Targeting genes elevated in the athlete's heart to improve function of the failing heart represents a new strategy for the treatment of heart failure.

心血管疾病影响着约370万澳大利亚人，心力衰竭是主要杀手之一，对我们的医疗保健系统和经济构成巨大负担。随着人口老龄化的加剧，这种情况可能会变得更糟。目前用于心力衰竭患者的治疗方法在很大程度上延迟了疾病进展，但通常不能显著改善心脏功能和生活质量。该提案的重点是通过识别心脏中因运动而升高的基因来靶向“良好”心脏生长的保护作用。靶向运动员心脏中升高的基因以改善衰竭心脏的功能代表了治疗心力衰竭的新策略。