Computational Modeling of Cardiac Electrical Response

心脏电反应的计算模型

• 批准号: 0408293
• 负责人: Gregery Buzzard
• 金额: $ 10万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0408293&HistoricalAwards=false
• 关键词: Computational; Modeling; Cardiac; Electrical; Response

Cardiac arrhythmias such as ventricular fibrillation are a major cause of morbidity and mortality in the United States. In this IGMS project, PI Greg Buzzard will spend a year working with scientists at Gene Network Sciences and Cornell University to develop computational models of heart cells and heart tissue. He will work in conjunction with these scientists to implement and refine a model of a single heart cell using experimental data collected at Cornell University, to couple models of single cells in order to model heart tissue, to use this model of heart tissue to study the mechanisms underlying ventricular fibrillation, and to explore possible new approaches to the numerical simulation of these models. Moreover, Buzzard will develop a strong set of skills in biological modeling that will enable him to continue this collaboration beyond the period of the grant and to take part in other interdisciplinary projects.This IGMS project is jointly supported by the MPS Office of Multidisciplinary Activities (OMA) and the Division of Mathematical Sciences (DMS).

在美国，心律失常如室颤是发病率和死亡率的主要原因。在这个IGMS项目中，PI Greg Buzzard将与基因网络科学和康奈尔大学的科学家合作一年，开发心脏细胞和心脏组织的计算模型。 他将与这些科学家合作，利用康奈尔大学收集的实验数据实现和改进单个心脏细胞的模型，耦合单细胞模型以模拟心脏组织，使用心脏组织模型研究心室颤动的机制，并探索这些模型数值模拟的可能新方法。 此外，Buzzard还将在生物建模方面培养出一套强大的技能，这将使他能够在资助期后继续这种合作，并参与其他跨学科项目。该IGMS项目由MPS多学科活动办公室（OMA）和数学科学部（DMS）共同支持。