Organic Ion-Molecule Chemistry

有机化学和高分子化学项目继续支持明尼苏达大学明尼阿波利斯分校化学系史蒂文·R·卡斯教授的工作。这项研究将扩展PI在高能有机分子气相化学方面的工作。这些实验研究将与高级计算相结合，以研究两性离子、抗芳香族分子、活性中间体和锂取代自由基的反应。两性离子是一种既带正电荷又带负电荷的物种，在合成、生物和材料化学中具有非凡的意义。建议的实验旨在提供有关电荷分离对这些重要物种的结构和稳定性的影响的基本信息。为了确定影响这些高能分子寿命和稳定性的因素，将对抗芳香族化合物和活性中间体进行研究。这些研究有望提供丰富的热力学和动力学信息，将影响从蛋白质组学到分子合成的各种应用。

With this renewal award, the Organic and Macromolecular Chemistry Program continues its support of the work of Professor Steven R. Kass of the Department of Chemistry at the University of Minnesota, Minneapolis, MN. The research will extend the PI's work on the gas phase chemistry of energetic organic molecules. These experimental studies will be combined with high-level computations to investigate the reactions of zwitterions, antiaromatic molecules, reactive intermediates, and lithium substituted radicals. Zwitterions, species with both a positive and negative charge, of are of extraordinary significance in synthetic, biological, and materials chemistry. The proposed experiments are designed to provide fundamental information concerning the effects of charge separation on the structure and stability of these important species. Investigations of antiaromatic compounds and reactive intermediates will be carried out in order to determine the factors that contribute to the lifetimes and stabilities of these highly energetic molecules.These studies are expected provide a wealth of thermodynamic and kinetic information that will impact upon applications ranging from proteomics to molecular synthesis.