Segregation in Multicomponent Macromolecular Systems

多组分大分子系统中的分离

• 批准号: 0414446
• 负责人: Monica Olvera
• 金额: $ 30万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0414446&HistoricalAwards=false
• 关键词: Segregation; Multicomponent; Macromolecular; Systems

This award supports theoretical research that will analyze the statistics andthermodynamics of self-associating neutral and charged macromolecules in various environments. In particular, we will determine the structure and phase diagram of solutions of macromolecules with site-specific interactions such as heterogeneous polymers with associating end groups and peptide amphiphile molecules. Heterogeneous molecules with associating end groups form micelles and/or clusters. When their concentration increases the clusters expand over the whole system leading to gel-like structures. The physical properties of these gels will be analyzed as a function of the functionality of the associating groups and the excluded volume of the molecules. We will also analyze the effect of charge on the polymer backbone and of the salt in the environment on the thermodynamics of charged chain solutions with strong site-specific attractions. The association of peptide amphiphile molecules into cylindrical micelles will be analyzed as a function of the concentration and charge of the peptide. We will include hydrogen bonding in the self-associating model and compare its effect on the micelle structure to peptides with dipoles perpendicular to the backbones. Mixtures of peptides amphiphiles of opposite charge will also be analyzed as candidates for cylindrical micelles with specific surface structures driven by the segregation of the This award supports theoretical research that will analyze the statistics and peptides.Research goals are to generate new models to guide the synthesis and fabrication of new materials involving heterogeneous macromolecules and multicomponent solutions. These systems are capable of self-organizing in a large number of remarkable structures. Our results will aid the design of various experimental systems including non-aqueous thermoreversible gels with controllable adhesive properties, and aqueous thermoreversible gels for drug delivery. Our studies on charge effects on strongly interacting heterogeneous macromolecules, on the other hand, are highly relevant to the understanding of the self-organization of many biological systems. Biological molecules fulfill a wide variety of amazing functions, and the understanding of the relation between their complex structure and their efficiency in performing specific tasks opens the possibility of creating new molecules for innovative applications. Moreover, our studies on peptide amphiphile are motivated by the need of creating new materials for significant medical applications, including nerve repair. We are particularly interested in understanding how different specific interactions, controlled by the synthesis and the environment, influence the properties of the final self-organized material.Educational goals will generate scientists capable of solving challenging and relevant problems for society. A well-balanced gender and ethnicity is kept in the group to prepare for a new generation of scientists. The group participates in local educational programs at the high school level. The group also interacts with scientists in Mexico and France.%%% This award supports theoretical research that will analyze the statistics and thermodynamics of self-associating neutral and charged macromolecules in various environments. In particular, we will determine the structure and phase diagram of solutions of macromolecules with site-specific interactions such as heterogeneous polymers with associating end groups and peptide amphiphile molecules. The study of these macromolecular solutions will lead to the design of new materials. It will also lead to a better understanding of biological materials, with potential applications in drug delivery, bio-adhesion and nerve repair.Educational goals will generate scientists capable of solving challenging and relevant problems for society. A well-balanced gender and ethnicity is kept in the group to prepare for a new generation of scientists. The group participates in local educational programs at the high school level. The group also interacts with scientists in Mexico and France.***

该奖项支持理论研究，将分析各种环境中自缔合中性和带电大分子的统计和热力学。特别是，我们将确定具有位点特异性相互作用的大分子溶液的结构和相图，例如具有相关端基的非均相聚合物和肽两亲分子。具有相关端基的异质分子形成胶束和/或团簇。当它们的浓度增加时，团簇在整个体系中膨胀，形成凝胶状结构。这些凝胶的物理性质将作为缔合基团的功能和分子的排除体积的函数来分析。我们还将分析聚合物主链上的电荷和环境中的盐对具有强位点特异性吸引力的带电链溶液热力学的影响。肽两亲分子结合成圆柱形胶束的过程将作为肽的浓度和电荷的函数进行分析。我们将在自缔合模型中包括氢键，并比较其对胶束结构的影响与垂直于骨架的偶极子肽。具有相反电荷的多肽两亲体混合物也将作为具有特定表面结构的圆柱形胶束的候选物进行分析，该奖项支持理论研究，将分析统计数据和多肽。研究目标是产生新的模型来指导涉及非均相大分子和多组分溶液的新材料的合成和制造。这些系统能够自组织成大量显著的结构。我们的研究结果将有助于各种实验系统的设计，包括具有可控粘附性能的非水热可逆凝胶，以及用于药物输送的水热可逆凝胶。另一方面，我们对强相互作用的异质大分子的电荷效应的研究，与许多生物系统的自组织的理解高度相关。生物分子具有各种各样的惊人功能，对其复杂结构与执行特定任务效率之间关系的理解，为创新应用创造了新分子的可能性。此外，我们对肽两亲体的研究是由创造重要医学应用的新材料的需要所驱动的，包括神经修复。我们特别感兴趣的是了解由合成和环境控制的不同特定相互作用如何影响最终自组织材料的性质。教育目标将培养能够为社会解决具有挑战性和相关性问题的科学家。为了培养新一代的科学家，团队中保持了性别和种族的平衡。该组织参加当地的高中教育项目。该小组还与墨西哥和法国的科学家进行交流。该奖项支持理论研究，将分析各种环境中自缔合中性和带电大分子的统计和热力学。特别是，我们将确定具有位点特异性相互作用的大分子溶液的结构和相图，例如具有相关端基的非均相聚合物和肽两亲分子。对这些大分子溶液的研究将导致新材料的设计。它还将导致对生物材料的更好理解，在药物递送、生物粘附和神经修复方面具有潜在的应用。教育目标将培养能够为社会解决具有挑战性和相关性问题的科学家。为了培养新一代的科学家，团队中保持了性别和种族的平衡。该组织参加当地的高中教育项目。该小组还与墨西哥和法国的科学家进行交流