Proton Transfer and Hydrogen Bonding in Organometallic Structure and Catalysis

本研究项目的重点是设计、合成和研究含有Bronsted碱性和有机金属（Lewis酸性）位点的双功能催化剂。在计算研究的辅助下，双功能配体将被设计和合成。在这些配体的过渡金属配合物的制备和表征之后，这些配合物将在以下方面进行探索：羟基化合物对炔和烯烃的反马尔可夫尼科夫加成、腈的水化、烷基醇和烷基酰胺的环化、末端炔对羰基化合物的加成以及烯烃的氢胺化。在有机和大分子化学项目的支持下，圣地亚哥州立大学化学和生物化学系的Douglas B. Grotjahn教授正在开发新的催化剂，旨在通过两个位点的相互作用实现重要的化学转化。催化作用使有机化合物的合成高效、环保。Grotjahn教授的研究利用了大自然催化剂和酶的设计原理，为催化反应提供了新的机制，并创造了能够影响全新反应的催化剂。

This research program focuses on the design, synthesis, and study of bifunctional catalysts containing both Bronsted basic and organometallic (Lewis acidic) sites. Assisted by calculational studies, bifunctional ligands will be designed and synthesized. Following preparation and characterization of transition metal complexes of these ligands, these complexes will be explored in the catalysis of the anti-Markovnikov addition of hydroxylic compounds to alkynes and alkenes, hydration of nitriles, cyclization of alkynols and alkynylamides, addition of terminal alkynes to carbonyl compounds, and hydroamination of alkenes.With the support of the Organic and Macromolecular Chemistry Program, Professor Douglas B. Grotjahn, of the Department of Chemistry and Biochemistry at San Diego State University, is developing new catalysts designed to effect important chemical transformations through two-site interactions. Catalysis enables the efficient and environmentally sound synthesis of organic compounds. By utilizing design principles inspired by Nature's catalysts, the enzymes, Professor Grotjahn's studies promise both new mechanisms for the catalysis of reactions and the creation of catalysts able to effect completely new reactions.