Proton Transfer and Hydrogen Bonding in Organometallic Structure and Catalysis

本研究计划致力于设计、合成和研究同时含有Bronsted碱性中心和有机金属(Lewis酸性)中心的双功能催化剂。在计算研究的辅助下，将设计和合成双功能配体。在这些配体的过渡金属络合物的制备和表征之后，这些络合物将被用于催化羟基化合物与炔烃和烯烃的反马尔可夫尼科夫加成反应、腈的水合反应、炔醇和炔酰胺的环化反应、末端炔烃与羰基化合物的加成反应以及烯烃的氢胺化反应。在有机化学和大分子化学项目的支持下，圣地亚哥州立大学化学和生物化学系的道格拉斯·B·格罗特贾恩教授正在开发新的催化剂，旨在通过两个位置的相互作用影响重要的化学转化。催化使有机化合物的合成高效且对环境无害。通过利用受自然催化剂(酶)启发的设计原则，格罗特扬教授的研究既承诺了反应催化的新机制，也承诺创造能够实现全新反应的催化剂。

This research program focuses on the design, synthesis, and study of bifunctional catalysts containing both Bronsted basic and organometallic (Lewis acidic) sites. Assisted by calculational studies, bifunctional ligands will be designed and synthesized. Following preparation and characterization of transition metal complexes of these ligands, these complexes will be explored in the catalysis of the anti-Markovnikov addition of hydroxylic compounds to alkynes and alkenes, hydration of nitriles, cyclization of alkynols and alkynylamides, addition of terminal alkynes to carbonyl compounds, and hydroamination of alkenes.With the support of the Organic and Macromolecular Chemistry Program, Professor Douglas B. Grotjahn, of the Department of Chemistry and Biochemistry at San Diego State University, is developing new catalysts designed to effect important chemical transformations through two-site interactions. Catalysis enables the efficient and environmentally sound synthesis of organic compounds. By utilizing design principles inspired by Nature's catalysts, the enzymes, Professor Grotjahn's studies promise both new mechanisms for the catalysis of reactions and the creation of catalysts able to effect completely new reactions.