Proton Transfer and Hydrogen Bonding in Organometallic Structure and Catalysis

有机金属结构和催化中的质子转移和氢键

• 批准号: 0415783
• 负责人: Douglas Grotjahn
• 金额: $ 37.8万
• 依托单位: San Diego State University Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0415783&HistoricalAwards=false
• 关键词: Proton; Transfer; Hydrogen; Bonding; Organometallic

This research program focuses on the design, synthesis, and study of bifunctional catalysts containing both Bronsted basic and organometallic (Lewis acidic) sites. Assisted by calculational studies, bifunctional ligands will be designed and synthesized. Following preparation and characterization of transition metal complexes of these ligands, these complexes will be explored in the catalysis of the anti-Markovnikov addition of hydroxylic compounds to alkynes and alkenes, hydration of nitriles, cyclization of alkynols and alkynylamides, addition of terminal alkynes to carbonyl compounds, and hydroamination of alkenes.With the support of the Organic and Macromolecular Chemistry Program, Professor Douglas B. Grotjahn, of the Department of Chemistry and Biochemistry at San Diego State University, is developing new catalysts designed to effect important chemical transformations through two-site interactions. Catalysis enables the efficient and environmentally sound synthesis of organic compounds. By utilizing design principles inspired by Nature's catalysts, the enzymes, Professor Grotjahn's studies promise both new mechanisms for the catalysis of reactions and the creation of catalysts able to effect completely new reactions.

本研究计划的重点是设计，合成和研究的双功能催化剂含有布朗斯台德碱性和有机金属（刘易斯酸）网站。在计算研究的辅助下，我们将设计并合成双功能配体。这些配体的过渡金属配合物的制备和表征后，这些配合物将探索在催化的反马尔可夫加成的羟基化合物的炔和烯烃，腈的水合，炔醇和炔酰胺的环化，加成的末端炔羰基化合物，和氢化胺化的alkenes.With有机和大分子化学程序的支持下，教授道格拉斯B。圣地亚哥州立大学化学和生物化学系的Grotjahn正在开发新的催化剂，旨在通过两点相互作用实现重要的化学转化。催化剂使有机化合物的高效和环境友好的合成成为可能。通过利用受大自然催化剂（酶）启发的设计原理，Grotjahn教授的研究承诺了催化反应的新机制和能够实现全新反应的催化剂的创造。