Acquisition of a 400 MHz Spectrometer and Upgrade of Departmental NMR Facility

在重大研究仪器（MRI）计划的支持下，圣地亚哥州立大学化学系将获得一台400 MHz核磁共振（NMR）光谱仪。该设备将使研究人员能够在以下领域进行研究：（1）有机结构和催化中的质子转移和氢键，（2）新的有机铜反应：机制和方法，（3）无机化学的新蝎形配体和硼和铁在有害藻类水华中的作用，（4）生物化学重要分子的高分辨率NMR衍生构象，（5）结合计算和实验方法设计蛋白质-蛋白质相互作用，和（6）霍利迪连接结合分子和靶DNA之间的相互作用。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些核磁共振研究的结果将对许多领域产生影响，特别是生物化学。

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at San Diego State University will acquire a 400 MHz nuclear magnetic resonance (NMR) Spectrometer. This equipment will enable researchers to carry out studies in the following areas: (1) Proton Transfer and Hydrogen Bonding in Organometallic Structure and Catalysis, (2) New Organocopper Reactions: Mechanisms and Methodology, (3) New Scorpionate Ligands for Inorganic Chemistry and The Role of Boron and Iron in Harmful Algal Blooms, (4) High Resolution NMR-Derived Conformations of Molecules of Biochemical Importance, (5) Combined Computational and Experimental Approaches for the Design of Protein-Protein Interactions, and (6) Interactions between Holliday Junction-Binding Molecules and Target DNA. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact a number of areas, especially biochemistry.