Arabidopsis 2010: Collaborative Research: Functional and Evolutionary Genomics of Drought Adaptation Networks

拟南芥 2010：合作研究：干旱适应网络的功能和进化基因组学

• 批准号: 0419542
• 负责人: Eli Stahl
• 金额: $ 5.07万
• 依托单位: University of Massachusetts, Dartmouth
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0419542&HistoricalAwards=false
• 关键词: Arabidopsis; 2010; Collaborative; Research; Functional

Drought stress is ubiquitous and has played an important selective role in the evolution of plant growth, development, and physiology. It is also a major limiting factor to crop productivity worldwide. This 2010 project will use genome-wide molecular techniques to study the quantitative genetics of adaptation to differences in water availability in the model plant, Arabidopsis thaliana. A major goal of the project is to map and identify genomic regions and characterize genes and gene networks that function in escape, avoidance, and tolerance of drought among plants adapted to habitats spanning extremes of water availability. In addition, new resources will be developed for the study of quantitative genetics in Arabidopsis, including a mapping population and a series of genetic lines capturing genes controlling key components of plant physiology related to drought adaptation. This project builds on the infrastructure of genomic data and tools developed by the Arabidopsis research community, and will link molecular variation of functional genes to evolutionary processes. The ultimate goal of this research is to determine why, as well as how, the Arabidopsis thaliana genome has evolved functional variation in traits important for adaptation to habitats differing in water availability.The significance of the proposed work in relation to the overall 2010 project objectives is twofold. First, most traits of ecological and agricultural significance are quantitative and influenced by many genes as well as by the environment. Unfortunately, little is known about the molecular genetic details underlying quantitative genetic variation. Understanding the genetics of quantitative variation will be necessary for a complete elucidation of the function of all Arabidopsis thaliana genes. In addition, results of this project will complement ongoing efforts to characterize the genetics of constitutive and inducible traits that enhance stress tolerance in plants. The study of naturally evolved variation is a largely unexplored avenue for understanding the molecular genetic basis of plant stress responses. Secondly, genetic mapping resources, genetic lines, and improved analytical methods developed through the project will facilitate future quantitative genetic studies of Arabidopsis thaliana. The broader impact of the proposed research includes integrated training for students and postdoctoral scholars in molecular genetics, evolutionary biology, physiology, and bioinformatics - skills necessary for the next generation of successful genomic scientists. All plant materials and associated genotypic data will be made available using The Arabidopsis Information Resource infrastructure (http://www.arabidopsis.org . Progress and details of particular aspects of the project will be available at the project website (http://orthos.bio.umassd.edu:8080/Arabidopsis/drought), available in October 2004.

干旱压力无处不在，并且在植物生长，发育和生理学的发展中发挥了重要的选择性作用。 这也是全球作物生产力的主要限制因素。该2010年的项目将使用全基因组分子技术来研究适应模型植物拟南芥水可用性差异的定量遗传学。 该项目的一个主要目标是绘制和识别基因组区域，并表征在逃生，回避和耐受性中起作用的基因和基因网络。 此外，将开发新的资源来研究拟南芥中的定量遗传学，包括映射种群和一系列捕获控制与干旱适应性有关植物生理的关键成分的基因的遗传线。该项目建立在拟南芥研究界开发的基因组数据和工具的基础架构的基础上，并将将功能基因的分子变化与进化过程联系起来。 这项研究的最终目的是确定为什么拟南芥基因组以及如何在适应水上栖息地的适应性栖息地的特征方面发展了功能差异。拟议工作在与整个2010年项目目标关系中的重要性是双重的。 首先，大多数生态和农业意义的特征都是定量的，受许多基因以及环境的影响。 不幸的是，关于分子遗传细节的基础定量遗传变异知之甚少。 对于完全阐明所有拟南芥基因的功能，了解定量变异的遗传学是必要的。 此外，该项目的结果将补充持续的努力，以表征构成性和诱导性状的遗传学，从而增强植物的胁迫耐受性。 对自然发展变异的研究是一条未开发的途径，用于理解植物应激反应的分子遗传基础。 其次，通过该项目开发的遗传学映射资源，遗传线和改进的分析方法将促进拟南芥的未来定量遗传研究。 拟议研究的更广泛影响包括针对学生和分子遗传学，进化生物学，生理学和生物信息学的综合培训 - 成功的基因组科学家所必需的技能。所有植物材料和相关的基因型数据都将使用拟南芥信息资源基础架构（http://www.arabidopsis.org。