Mechanisms of absolute and relative timing in circuit processing of auditory space (B02)

我们的最新发现表明，在声音定位电路中，轴突和突触的传递特性可以根据输入时间的特定要求进行优化。基于这些见解，我们将在下一个资助期解决以下问题：1)调节动作电位速度的解剖学特化背后的发育机制是什么？2)脑花萼持续突触延迟是否有结构基础？3)在复杂听力环境中，相对抑制时间和绝对抑制时间在声音定位中的作用是什么？这些问题将通过组织学和电生理方法以及细胞培养来研究。

Our latest findings suggest an optimization of axonal and synaptic transmission properties to the specific demands of input timing in sound localization circuits. Based on these insights, we will address the following questions in the next funding period: 1) What are the developmental mechanisms underlying anatomical specializations for tuning action potential velocity? 2) Is there a structural basis for constant synaptic delays in calyces of Held? 3) What is the role of relative and absolute timing of inhibition for sound localization in complex listening contexts? These questions will be investigated with histological and electrophysiological methods as well as cell culture.