Mathematics of Neurite Outgrowth and Pathfinding

神经突生长和寻路的数学

• 批准号: 0424882
• 负责人: Troy Shinbrot
• 金额: $ 10万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-15 至 2007-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0424882&HistoricalAwards=false
• 关键词: Mathematics; Neurite; Outgrowth; Pathfinding

The overarching objective of the work proposed here is to support a productive interdisciplinary collaboration that will simultaneously generate meaningful quantitative research results in the neurosciences and foster the acquisition of the physiological background that will permit me to develop an independent research program in quantitative modeling of neuronal morphogenesis. The proposed work will be performed at the Center for Collaborative Neuroscience at Rutgers University, and will focus on developmental and regenerative mechanisms associated with Dorsal Root Ganglion (DRG) neurons and their associated glia. This work will involve two research projects to be performed under the guidance of Prof. Wise Young, MD PhD and Chair of Cell Biology & Neuroscience, and Prof. Martin Grumet, PhD and Director of the Center, in close collaboration with appropriate faculty, postdoctoral fellows, graduate students, and visiting scientists affiliated with the Center. The aims of this work are to quantitative test the hypotheses that morphogenesis of Dorsal Root Ganglion (DRG) neurites in vitro can be well described by a stochastic model, and that the function of such stochastic morphogenesis is to efficiently explore space in search of targets. The approach that will be used to achieve these aims will involve direct numerical simulations of axonal and glial structures that are validated and modified to accord with 3D imaging of neuronal cultures. Throughout this work, the guiding objective will be to use modeling to derive concrete, testable predictions.This IGMS project is jointly supported by the MPS Office of Multidisciplinary Activities (OMA) and the Division of Mathematical Sciences (DMS).

这里提出的工作的总体目标是支持富有成效的跨学科合作，同时在神经科学领域产生有意义的定量研究结果，并促进生理背景的获取，这将使我能够在神经元形态发生的定量建模方面开发独立的研究计划。 拟议的工作将在罗格斯大学合作神经科学中心进行，重点研究与背根神经节（DRG）神经元及其相关神经胶质细胞相关的发育和再生机制。 这项工作将涉及两个研究项目，这些项目将在医学博士、细胞生物学和神经科学系主任 Wise Young 教授和该中心主任 Martin Grumet 教授的指导下进行，并与该中心相关的教职人员、博士后研究员、研究生和访问科学家密切合作。 这项工作的目的是定量测试这样的假设：体外背根神经节（DRG）神经突的形态发生可以通过随机模型很好地描述，并且这种随机形态发生的功能是有效地探索空间以寻找目标。 用于实现这些目标的方法将涉及轴突和神经胶质结构的直接数值模拟，这些结构经过验证和修改以符合神经元培养物的 3D 成像。 在整个工作中，指导目标将是使用建模来得出具体的、可测试的预测。该 IGMS 项目由 MPS 多学科活动办公室 (OMA) 和数学科学部 (DMS) 共同支持。