SENSORS: Cell-Based Sensors that link Nanotechnology with Microfluidics

传感器：将纳米技术与微流体联系起来的基于细胞的传感器

• 批准号: 0428573
• 负责人: Maribel Vazquez
• 金额: $ 34.11万
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0428573&HistoricalAwards=false
• 关键词: SENSORS; Cell; Based; Sensors; link

0428573VazquezThis project will specifically develop an original microfluidic network (the uStar) to study the effects of multivalent nanosensors on the fundamental cell process of chemotaxic migration. The system will enable single-cell imaging and quantitative analysis of nanosensor dynamics once inducted within viable fibroblast cells in real-time. Nanosensors will be developed to target the intracellular protein, Growth Factor Receptor Bound-2 (GRB2), known to initiate chemotaxis signaling cascades when activated by the chemoattractant growth factors studied in this project.

0428573 Vazquez该项目将专门开发一个原始的微流体网络（uStar），以研究多价纳米传感器对趋化性迁移的基本细胞过程的影响。该系统将使单细胞成像和纳米传感器动态的定量分析，一旦在活的成纤维细胞内实时诱导。纳米传感器将被开发为靶向细胞内蛋白，生长因子受体结合-2（GRB 2），已知启动趋化性信号级联反应时，由本项目中研究的趋化生长因子激活。