NER: Intracellular Regulation via Multivalent Nanoprobes

0403971 Vazquez这项探索性研究建议开发一个细胞功能变化的定量测量方法，该变化是由启动趋化信号级联所需的一种接头蛋白-生长因子受体结合2(Grb2)的多价结合所引起的趋化迁移。细胞行为的可测量变化将导致使用多价纳米探针改变或指导细胞行为作为一种新的治疗干预手段的令人兴奋的可能性。

0403971VazquezThis exploratory research proposes to develop quantitative measures of the changes in one cell function, chemotaxic migration, induced by the multivalent binding of one adapter protein needed to initiate chemotaxic signal cascades, Growth Factor Receptor Bound-2 (GRB2). Measurable changes in cell behavior will lead to the exciting possibility of using multivalent nanoprobes to alter or direct cell behavior as a new meansfor therapeutic intervention.