NER: Intracellular Regulation via Multivalent Nanoprobes

NER：通过多价纳米探针进行细胞内调节

• 批准号: 0403971
• 负责人: Maribel Vazquez
• 金额: --
• 依托单位: CUNY City College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0403971&HistoricalAwards=false
• 关键词: NER; Intracellular; Regulation; via; Multivalent

0403971VazquezThis exploratory research proposes to develop quantitative measures of the changes in one cell function, chemotaxic migration, induced by the multivalent binding of one adapter protein needed to initiate chemotaxic signal cascades, Growth Factor Receptor Bound-2 (GRB2). Measurable changes in cell behavior will lead to the exciting possibility of using multivalent nanoprobes to alter or direct cell behavior as a new meansfor therapeutic intervention.

0403971 Vazquez该探索性研究提出开发一种细胞功能变化的定量测量，趋化性迁移，其由启动趋化性信号级联所需的一种衔接蛋白，生长因子受体结合-2（GRB 2）的多价结合诱导。细胞行为的可测量变化将导致使用多价纳米探针改变或指导细胞行为作为治疗干预的新手段的令人兴奋的可能性。